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Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity: MODEL FOR THE POTENTIAL INVOLVEMENT OF THE HYPOXIA-INDUCIBLE FACTOR PATHWAY IN PARKINSON DISEASE

Hypoxia-inducible factor (HIF) plays an important role in cell survival by regulating iron, antioxidant defense, and mitochondrial function. Pharmacological inhibitors of the iron-dependent enzyme class prolyl hydroxylases (PHD), which target α subunits of HIF proteins for degradation, have recently...

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Dettagli Bibliografici
Autori principali: Lee, Donna W., Rajagopalan, Subramanian, Siddiq, Ambreena, Gwiazda, Roberto, Yang, Lichuan, Beal, M. Flint, Ratan, Rajiv R., Andersen, Julie K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781452/
https://ncbi.nlm.nih.gov/pubmed/19679656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.000638
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