Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

Although the etiology of Parkinson's disease (PD) remains unclear, ample empirical evidence suggests that oxidative stress is a major player in the development of PD and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. Nuclear factor E2-related factor 2 (Nrf2) is a redox-se...

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Dades bibliogràfiques
Autors principals: Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A., Hushpulian, Dmitry M., Liby, Karen T., Williams, Charlotte R., Yamamoto, Masayuki, Kensler, Thomas W., Ratan, Rajiv R., Sporn, Michael B., Beal, M. Flint, Gazaryan, Irina G., Thomas, Bobby
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2013
Matèries:
Original Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514006/
https://ncbi.nlm.nih.gov/pubmed/22746536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4491
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