Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

Although the etiology of Parkinson's disease (PD) remains unclear, ample empirical evidence suggests that oxidative stress is a major player in the development of PD and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. Nuclear factor E2-related factor 2 (Nrf2) is a redox-se...

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Autori principali: Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A., Hushpulian, Dmitry M., Liby, Karen T., Williams, Charlotte R., Yamamoto, Masayuki, Kensler, Thomas W., Ratan, Rajiv R., Sporn, Michael B., Beal, M. Flint, Gazaryan, Irina G., Thomas, Bobby
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2013
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Original Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514006/
https://ncbi.nlm.nih.gov/pubmed/22746536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4491
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