Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

Although the etiology of Parkinson's disease (PD) remains unclear, ample empirical evidence suggests that oxidative stress is a major player in the development of PD and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. Nuclear factor E2-related factor 2 (Nrf2) is a redox-se...

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Hauptverfasser: Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A., Hushpulian, Dmitry M., Liby, Karen T., Williams, Charlotte R., Yamamoto, Masayuki, Kensler, Thomas W., Ratan, Rajiv R., Sporn, Michael B., Beal, M. Flint, Gazaryan, Irina G., Thomas, Bobby
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2013
Schlagworte:
Original Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514006/
https://ncbi.nlm.nih.gov/pubmed/22746536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4491
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