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Attenuation of MPTP Neurotoxicity by Rolipram, a Specific Inhibitor of Phosphodiesterase IV
Rolipram, a specific inhibitor of the phosphodiesterase IV (PDE IV), has recently been shown to exert neuroprotective effects in an Alzheimer transgenic mouse model and in hypoxic-ischemic damage in the rat brain. It activates the cAMP-dependent protein kinase (PKA)/cAMP regulatory element-binding p...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3261655/ https://ncbi.nlm.nih.gov/pubmed/18328479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2007.02.010 |
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