Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

Although the etiology of Parkinson's disease (PD) remains unclear, ample empirical evidence suggests that oxidative stress is a major player in the development of PD and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. Nuclear factor E2-related factor 2 (Nrf2) is a redox-se...

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Detalhes bibliográficos
Main Authors: Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A., Hushpulian, Dmitry M., Liby, Karen T., Williams, Charlotte R., Yamamoto, Masayuki, Kensler, Thomas W., Ratan, Rajiv R., Sporn, Michael B., Beal, M. Flint, Gazaryan, Irina G., Thomas, Bobby
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514006/
https://ncbi.nlm.nih.gov/pubmed/22746536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4491
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