The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding

von Bakan, Ahmet, Bahar, Ivet
Veröffentlicht 2009

COMPUTATIONAL GENERATION INHIBITOR-BOUND CONFORMERS OF P38 MAP KINASE AND COMPARISON WITH EXPERIMENTS

von BAKAN, AHMET, BAHAR, IVET
Veröffentlicht in Pac Symp Biocomput (2011)

ProDy: Protein Dynamics Inferred from Theory and Experiments

von Bakan, Ahmet, Meireles, Lidio M., Bahar, Ivet
Veröffentlicht 2011

Pre-existing soft modes of motion uniquely defined by native contact topology facilitate ligand binding to proteins

von Meireles, Lidio, Gur, Mert, Bakan, Ahmet, Bahar, Ivet
Veröffentlicht 2011

Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules

von Bakan, Ahmet, Nevins, Neysa, Lakdawala, Ami S., Bahar, Ivet
Veröffentlicht 2012

Normal Mode Analysis of Biomolecular Structures: Functional Mechanisms of Membrane Proteins

von Bahar, Ivet, Lezon, Timothy R., Bakan, Ahmet, Shrivastava, Indira H.
Veröffentlicht 2010

Coupling between Catalytic Loop Motions and Enzyme Global Dynamics

von Kurkcuoglu, Zeynep, Bakan, Ahmet, Kocaman, Duygu, Bahar, Ivet, Doruker, Pemra
Veröffentlicht 2012

Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening

von Bakan, Ahmet, Lazo, John S, Wipf, Peter, Brummond, Kay M, Bahar, Ivet
Veröffentlicht 2008

Inhibition of Peroxidase Activity of Cytochrome c: De Novo Compound Discovery and Validation

von Bakan, Ahmet, Kapralov, Alexandr A., Bayir, Hulya, Hu, Feizhou, Kagan, Valerian E., Bahar, Ivet
Veröffentlicht in Mol Pharmacol (2015)

Evol and ProDy for bridging protein sequence evolution and structural dynamics

von Bakan, Ahmet, Dutta, Anindita, Mao, Wenzhi, Liu, Ying, Chennubhotla, Chakra, Lezon, Timothy R., Bahar, Ivet
Veröffentlicht 2014

Development of Small-Molecule PUMA Inhibitors for Mitigating Radiation-Induced Cell Death

von Mustata, Gabriela, Li, Mei, Zevola, Nicki, Bakan, Ahmet, Zhang, Lin, Epperly, Michael, Greenberger, Joel S., Yu, Jian, Bahar, Ivet
Veröffentlicht 2011

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

von Molina, Gabriela, Vogt, Andreas, Bakan, Ahmet, Dai, Weixiang, de Oliveira, Pierre Queiroz, Znosko, Wade, Smithgall, Thomas E., Bahar, Ivet, Lazo, John S., Day, Billy W., Tsang, Michael
Veröffentlicht 2009

In Vivo Structure-Activity Relationship Studies Support Allosteric Targeting of a Dual Specificity Phosphatase

von Korotchenko, Vasiliy N., Saydmohammed, Manush, Vollmer, Laura L., Bakan, Ahmet, Sheetz, Kyle, Debiec, Karl T., Greene, Kristina A., Agliori, Christine S., Bahar, Ivet, Day, Billy W., Vogt, Andreas, Tsang, Michael
Veröffentlicht 2014

Designing Inhibitors of Cytochrome c/Cardiolipin Peroxidase Complexes: Mitochondria-Targeted Imidazole-Substituted Fatty Acids

von Jiang, Jianfei, Bakan, Ahmet, Kapralov, Alexandr A., Silva, K. Ishara, Huang, Zhentai, Amoscato, Andrew A., Peterson, James, Garapati, Venkata Krishna, Saxena, Sunil, Bayir, Hülya, Atkinson, Jeffrey, Bahar, Ivet, Kagan, Valerian E.
Veröffentlicht 2014

Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans

von Bhushan, Abhinav, Senutovitch, Nina, Bale, Shyam S, McCarty, William J, Hegde, Manjunath, Jindal, Rohit, Golberg, Inna, Berk Usta, O, Yarmush, Martin L, Vernetti, Lawrence, Gough, Albert, Bakan, Ahmet, Shun, Tong Ying, Biasio, Richard, Lansing Taylor, D
Veröffentlicht 2013

In Vitro Platforms for Evaluating Liver Toxicity

von Bale, Shyam Sundhar, Vernetti, Lawrence, Senutovitch, Nina, Jindal, Rohit, Hegde, Manjunath, Gough, Albert, McCarty, William J, Bakan, Ahmet, Bhushan, Abhinav, Shun, Tong Ying, Golberg, Inna, DeBiasio, Richard, Usta, Berk Osman, Taylor, D. Lansing, Yarmush, Martin L.
Veröffentlicht 2014