Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

The dual specificity phosphatase 6 (Dusp6) functions as a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal regulated kinase (ERK) 1 and 2. We have identified a small molecule inhibitor of Dusp6, (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dih...

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Detalhes bibliográficos
Main Authors: Molina, Gabriela, Vogt, Andreas, Bakan, Ahmet, Dai, Weixiang, de Oliveira, Pierre Queiroz, Znosko, Wade, Smithgall, Thomas E., Bahar, Ivet, Lazo, John S., Day, Billy W., Tsang, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771339/
https://ncbi.nlm.nih.gov/pubmed/19578332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.190
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