Učitavanje...
The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding
The conformational flexibility of target proteins continues to be a major challenge in accurate modeling of protein–inhibitor interactions. A fundamental issue, yet to be clarified, is whether the observed conformational changes are controlled by the protein or induced by the inhibitor. Although the...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2728110/ https://ncbi.nlm.nih.gov/pubmed/19706521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904214106 |
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