Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans

Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and other insults. Societal pressures are also focusing on reduction of and, ultimately, replacem...

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Bibliographische Detailangaben
Hauptverfasser: Bhushan, Abhinav, Senutovitch, Nina, Bale, Shyam S, McCarty, William J, Hegde, Manjunath, Jindal, Rohit, Golberg, Inna, Berk Usta, O, Yarmush, Martin L, Vernetti, Lawrence, Gough, Albert, Bakan, Ahmet, Shun, Tong Ying, Biasio, Richard, Lansing Taylor, D
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028964/
https://ncbi.nlm.nih.gov/pubmed/24565476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/scrt377
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