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Inhibition of Peroxidase Activity of Cytochrome c: De Novo Compound Discovery and Validation
Cytochrome c (cyt c) release from mitochondria is accepted to be the point of no return for eliciting a cascade of interactions that lead to apoptosis. A strategy for containing sustained apoptosis is to reduce the mitochondrial permeability pore opening. Pore opening is enhanced by peroxidase activ...
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| 發表在: | Mol Pharmacol |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551054/ https://ncbi.nlm.nih.gov/pubmed/26078313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.097816 |
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