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NO(●) Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis

We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO(●) suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LOX) complexed with PE-binding protein 1 (PEBP1). Ho...

詳細記述

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書誌詳細
出版年:Int J Mol Sci
主要な著者: Mikulska-Ruminska, Karolina, Anthonymuthu, Tamil S., Levkina, Anastasia, Shrivastava, Indira H., Kapralov, Alexandr A., Bayır, Hülya, Kagan, Valerian E., Bahar, Ivet
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156958/
https://ncbi.nlm.nih.gov/pubmed/34067535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105253
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