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NO(●) Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis
We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO(●) suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LOX) complexed with PE-binding protein 1 (PEBP1). Ho...
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| Veröffentlicht in: | Int J Mol Sci |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8156958/ https://ncbi.nlm.nih.gov/pubmed/34067535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105253 |
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