Empowerment of 15-lipoxygenase catalytic competence in selective oxidation of membrane ETE-PE to ferroptotic death signals, HpETE-PE

sn2-15-HpETE-PE generated by mammalian 15-lipoxygenase/phosphatidylethanolamine binding protein-1 (PEBP1) complex is a death signal in a recently identified type of programmed cell demise, ferroptosis. How the enzymatic complex selects sn2-ETE-PE as the substrate among 1 of ~100 total oxidizable mem...

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Publicado no:J Am Chem Soc
Main Authors: Anthonymuthu, Tamil S, Kenny, Elizabeth M, Shrivastava, Indira H, Tyurina, Yulia Y, Hier, Zachary E, Ting, Hsiu-Chi, Dar, Haider H., Tyurin, Vladimir A, Nesterova, Anastasia, Amoscato, Andrew A, Mikulska-Ruminska, Karolina, Rosenbaum, Joel C, Mao, Gaowei, Zhao, Jinming, Conrad, Marcus, Kellum, John A, Wenzel, Sally E, VanDemark, Andrew P, Bahar, Ivet, Kagan, Valerian E, Bayɪr, Hülya
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622169/
https://ncbi.nlm.nih.gov/pubmed/30525572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b09913
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