Redox Lipid Reprogramming Commands Susceptibility of Macrophages and Microglia to Ferroptotic Death.

Ferroptotic death is the penalty for lost control over three processes – iron metabolism, lipid peroxidation and thiol regulation – common for pro-inflammatory environment where professional phagocytes fulfill their functions yet survive. We hypothesized that redox reprogramming of 15-lipoxygenase (...

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Publicado no:Nat Chem Biol
Main Authors: Kapralov, Alexandr A., Yang, Qin, Dar, Haider H., Tyurina, Yulia Y., Anthonymuthu, Tamil S., Kim, Rina, St. Croix, Claudette M., Mikulska-Ruminska, Karolina, Liu, Bing, Shrivastava, Indira H., Tyurin, Vladimir A., Ting, Hsiu-Chi, Wu, Yijen L., Gao, Yuan, Shurin, Galina V., Artyukhova, Margarita A., Ponomareva, Liubov A., Timashev, Peter S., Domingues, Rosario M., Stoyanovsky, Detcho A., Greenberger, Jeol S., Mallampalli, Rama K., Bahar, Ivet, Gabrilovich, Dmitry I., Bayir, Hülya, Kagan, Valerian E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233108/
https://ncbi.nlm.nih.gov/pubmed/32080625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0462-8
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