A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO(•) sabotage of theft-ferroptosis

Ferroptosis is a redox-driven type of regulated cell death program arising from maladaptation of three metabolic pathways: glutathione homeostasis, iron handling and lipid peroxidation. Though GSH/Gpx4 is the predominant system detoxifying phospholipid hydroperoxides (PLOOH) in mammalian cells, rece...

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Vydáno v:Redox Biol
Hlavní autoři: Dar, Haider H., Anthonymuthu, Tamil S., Ponomareva, Liubov A., Souryavong, Austin B., Shurin, Galina V., Kapralov, Alexandr O., Tyurin, Vladimir A., Lee, Janet S., Mallampalli, Rama K., Wenzel, Sally E., Bayir, Hülya, Kagan, Valerian E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Articles from the Special Issue on Redox signaling in the pathogenesis and treatments of acute lung injury and beyond, Edited by: Dr. Lin Mantell, Dr. Peter Vitiello and Dr. Eva Nozik
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8227829/
https://ncbi.nlm.nih.gov/pubmed/34167028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.102045
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