A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO(•) sabotage of theft-ferroptosis

Ferroptosis is a redox-driven type of regulated cell death program arising from maladaptation of three metabolic pathways: glutathione homeostasis, iron handling and lipid peroxidation. Though GSH/Gpx4 is the predominant system detoxifying phospholipid hydroperoxides (PLOOH) in mammalian cells, rece...

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Pubblicato in:Redox Biol
Autori principali: Dar, Haider H., Anthonymuthu, Tamil S., Ponomareva, Liubov A., Souryavong, Austin B., Shurin, Galina V., Kapralov, Alexandr O., Tyurin, Vladimir A., Lee, Janet S., Mallampalli, Rama K., Wenzel, Sally E., Bayir, Hülya, Kagan, Valerian E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
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Articles from the Special Issue on Redox signaling in the pathogenesis and treatments of acute lung injury and beyond, Edited by: Dr. Lin Mantell, Dr. Peter Vitiello and Dr. Eva Nozik
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8227829/
https://ncbi.nlm.nih.gov/pubmed/34167028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.102045
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