Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

Ferroptosis is a death program executed via selective oxidation of arachidonic acid–phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues, ferroptosis has been pathogenically associated with brain, kidney, and liver injury/diseases. We discovered that a prokaryotic ba...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Dar, Haider H., Tyurina, Yulia Y., Mikulska-Ruminska, Karolina, Shrivastava, Indira, Ting, Hsiu-Chi, Tyurin, Vladimir A., Krieger, James, St. Croix, Claudette M., Watkins, Simon, Bayir, Erkan, Mao, Gaowei, Armbruster, Catherine R., Kapralov, Alexandr, Wang, Hong, Parsek, Matthew R., Anthonymuthu, Tamil S., Ogunsola, Abiola F., Flitter, Becca A., Freedman, Cody J., Gaston, Jordan R., Holman, Theodore R., Pilewski, Joseph M., Greenberger, Joel S., Mallampalli, Rama K., Doi, Yohei, Lee, Janet S., Bahar, Ivet, Bomberger, Jennifer M., Bayır, Hülya, Kagan, Valerian E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159971/
https://ncbi.nlm.nih.gov/pubmed/30198910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99490
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