Oxidized Arachidonic/Adrenic Phosphatidylethanolamines Navigate Cells to Ferroptosis

Enigmatic lipid peroxidation products have been claimed as the proximate executioners of ferroptosis - a specialized death program triggered by insufficiency of glutathione peroxidase 4 (GPX4). Here, by using quantitative redox lipidomics, reverse genetics, bioinformatics and systems biology we disc...

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Publicado no:Nat Chem Biol
Main Authors: Kagan, Valerian E., Mao, Gaowei, Qu, Feng, Angeli, Jose Pedro Friedmann, Doll, Sebastian, Croix, Claudette St, Dar, Haider Hussain, Liu, Bing, Tyurin, Vladimir A., Ritov, Vladimir B., Kapralov, Alexandr A., Amoscato, Andrew A., Jiang, Jianfei, Anthonymuthu, Tamil, Mohammadyani, Dariush, Yang, Qin, Proneth, Bettina, Klein-Seetharaman, Judith, Watkins, Simon, Bahar, Ivet, Greenberger, Joel, Mallampalli, Rama K., Stockwell, Brent R., Tyurina, Yulia Y., Conrad, Marcus, Bayır, Hülya
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506843/
https://ncbi.nlm.nih.gov/pubmed/27842066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2238
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