Mitochondrial Redox Opto-Lipidomics Reveals Mono-Oxygenated Cardiolipins as Pro-Apoptotic Death Signals

While opto-genetics has proven to have tremendous value in revealing the functions of the macromolecular machinery in cells, it is not amenable to exploration of small molecules such as phospholipids (PLs). Here, we describe a redox opto-lipidomics approach based on a combination of high affinity li...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Chem Biol
Prif Awduron: Mao, Gaowei, Qu, Feng, St. Croix, Claudette M., Tyurina, Yulia Y., Planas-Iglesias, Joan, Jiang, Jianfei, Huang, Zhentai, Amoscato, Andrew A., Tyurin, Vladimir A., Kapralov, Alexandr A., Cheikhi, Amin, Maguire, John, Klein-Seetharaman, Judith, Bayır, Hülya, Kagan, Valerian E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741079/
https://ncbi.nlm.nih.gov/pubmed/26697918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00737
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