Mitochondrial Redox Opto-Lipidomics Reveals Mono-Oxygenated Cardiolipins as Pro-Apoptotic Death Signals

While opto-genetics has proven to have tremendous value in revealing the functions of the macromolecular machinery in cells, it is not amenable to exploration of small molecules such as phospholipids (PLs). Here, we describe a redox opto-lipidomics approach based on a combination of high affinity li...

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Publicado no:ACS Chem Biol
Main Authors: Mao, Gaowei, Qu, Feng, St. Croix, Claudette M., Tyurina, Yulia Y., Planas-Iglesias, Joan, Jiang, Jianfei, Huang, Zhentai, Amoscato, Andrew A., Tyurin, Vladimir A., Kapralov, Alexandr A., Cheikhi, Amin, Maguire, John, Klein-Seetharaman, Judith, Bayır, Hülya, Kagan, Valerian E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741079/
https://ncbi.nlm.nih.gov/pubmed/26697918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00737
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