Redox Lipid Reprogramming Commands Susceptibility of Macrophages and Microglia to Ferroptotic Death.

Ferroptotic death is the penalty for lost control over three processes – iron metabolism, lipid peroxidation and thiol regulation – common for pro-inflammatory environment where professional phagocytes fulfill their functions yet survive. We hypothesized that redox reprogramming of 15-lipoxygenase (...

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Pubblicato in:Nat Chem Biol
Autori principali: Kapralov, Alexandr A., Yang, Qin, Dar, Haider H., Tyurina, Yulia Y., Anthonymuthu, Tamil S., Kim, Rina, St. Croix, Claudette M., Mikulska-Ruminska, Karolina, Liu, Bing, Shrivastava, Indira H., Tyurin, Vladimir A., Ting, Hsiu-Chi, Wu, Yijen L., Gao, Yuan, Shurin, Galina V., Artyukhova, Margarita A., Ponomareva, Liubov A., Timashev, Peter S., Domingues, Rosario M., Stoyanovsky, Detcho A., Greenberger, Jeol S., Mallampalli, Rama K., Bahar, Ivet, Gabrilovich, Dmitry I., Bayir, Hülya, Kagan, Valerian E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233108/
https://ncbi.nlm.nih.gov/pubmed/32080625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0462-8
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