PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Ferroptosis is a form of programmed cell death pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsaturated fatty acids as substrates. Mechanisms of the altered 15-LO...

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Pubblicato in:Cell
Autori principali: Wenzel, Sally E., Tyurina, Yulia Y., Zhao, Jinming, St. Croix, Claudette M., Dar, Haider H., Mao, Gaowei, Tyurin, Vladimir A., Anthonymuthu, Tamil S., Kapralov, Alexandr A., Amoscato, Andrew A., Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Kenny, Elizabeth, Yang, Qin, Rosenbaum, Joel C., Sparvero, Louis J., Emlet, David R., Wen, Xiaoyan, Minami, Yoshinori, Qu, Feng, Watkins, Simon C., Holman, Theodore R., VanDemark, Andrew P., Kellum, John A., Bahar, Ivet, Bayır, Hülya, Kagan, Valerian E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683852/
https://ncbi.nlm.nih.gov/pubmed/29053969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.044
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