PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Ferroptosis is a form of programmed cell death pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsaturated fatty acids as substrates. Mechanisms of the altered 15-LO...

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Publicado no:Cell
Main Authors: Wenzel, Sally E., Tyurina, Yulia Y., Zhao, Jinming, St. Croix, Claudette M., Dar, Haider H., Mao, Gaowei, Tyurin, Vladimir A., Anthonymuthu, Tamil S., Kapralov, Alexandr A., Amoscato, Andrew A., Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Kenny, Elizabeth, Yang, Qin, Rosenbaum, Joel C., Sparvero, Louis J., Emlet, David R., Wen, Xiaoyan, Minami, Yoshinori, Qu, Feng, Watkins, Simon C., Holman, Theodore R., VanDemark, Andrew P., Kellum, John A., Bahar, Ivet, Bayır, Hülya, Kagan, Valerian E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683852/
https://ncbi.nlm.nih.gov/pubmed/29053969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.044
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