PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells

Temporally harmonized elimination of damaged or unnecessary organelles and cells is a prerequisite of health. Under Type 2 inflammatory conditions, human airway epithelial cells (HAECs) generate proferroptotic hydroperoxy-arachidonoyl-phosphatidylethanolamines (HpETE-PEs) as proximate death signals....

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Zhao, Jinming, Dar, Haider H., Deng, Yanhan, St. Croix, Claudette M., Li, Zhipeng, Minami, Yoshinori, Shrivastava, Indira H., Tyurina, Yulia Y., Etling, Emily, Rosenbaum, Joel C., Nagasaki, Tadao, Trudeau, John B., Watkins, Simon C., Bahar, Ivet, Bayır, Hülya, VanDemark, Andy P., Kagan, Valerian E., Wenzel, Sally E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2020
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321965/
https://ncbi.nlm.nih.gov/pubmed/32513718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921618117
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