PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells

Temporally harmonized elimination of damaged or unnecessary organelles and cells is a prerequisite of health. Under Type 2 inflammatory conditions, human airway epithelial cells (HAECs) generate proferroptotic hydroperoxy-arachidonoyl-phosphatidylethanolamines (HpETE-PEs) as proximate death signals....

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhao, Jinming, Dar, Haider H., Deng, Yanhan, St. Croix, Claudette M., Li, Zhipeng, Minami, Yoshinori, Shrivastava, Indira H., Tyurina, Yulia Y., Etling, Emily, Rosenbaum, Joel C., Nagasaki, Tadao, Trudeau, John B., Watkins, Simon C., Bahar, Ivet, Bayır, Hülya, VanDemark, Andy P., Kagan, Valerian E., Wenzel, Sally E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321965/
https://ncbi.nlm.nih.gov/pubmed/32513718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921618117
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