PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells

Temporally harmonized elimination of damaged or unnecessary organelles and cells is a prerequisite of health. Under Type 2 inflammatory conditions, human airway epithelial cells (HAECs) generate proferroptotic hydroperoxy-arachidonoyl-phosphatidylethanolamines (HpETE-PEs) as proximate death signals....

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhao, Jinming, Dar, Haider H., Deng, Yanhan, St. Croix, Claudette M., Li, Zhipeng, Minami, Yoshinori, Shrivastava, Indira H., Tyurina, Yulia Y., Etling, Emily, Rosenbaum, Joel C., Nagasaki, Tadao, Trudeau, John B., Watkins, Simon C., Bahar, Ivet, Bayır, Hülya, VanDemark, Andy P., Kagan, Valerian E., Wenzel, Sally E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321965/
https://ncbi.nlm.nih.gov/pubmed/32513718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921618117
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