Reduced penetrance of pathogenic ACMG variants in a deeply phenotyped cohort study and evaluation of ClinVar classification over time

by van Rooij, Jeroen, Arp, Pascal, Broer, Linda, Verlouw, Joost, van Rooij, Frank, Kraaij, Robert, Uitterlinden, André, Verkerk, Annemieke J. M. H.
Published in Genet Med (2020)

Vitamin D Binding Protein Genotype and Osteoporosis

by Fang, Yue, van Meurs, Joyce B. J., Arp, Pascal, van Leeuwen, Johannes P. T., Hofman, Albert, Pols, Huibert A. P., Uitterlinden, André G.
Published 2009

Telomere Length and the Risk of Alzheimer’s Disease: The Rotterdam Study

by Fani, Lana, Hilal, Saima, Sedaghat, Sanaz, Broer, Linda, Licher, Silvan, Arp, Pascal P., van Meurs, Joyce B.J., Ikram, M. Kamran, Ikram, M. Arfan
Published in J Alzheimers Dis (2020)

The interleukin-6 –174 G/C promoter polymorphism and arterial stiffness; the Rotterdam Study

by Sie, Mark PS, Mattace-Raso, Francesco US, Uitterlinden, André G, Arp, Pascal P, Hofman, Albert, Pols, Huibert AP, Hoeks, Arnold PG, Reneman, Robert S, Asmar, Roland, van Duijn, Cornelia M, Witteman, Jacqueline CM
Published 2008

Population-specific genetic variation in large sequencing data sets: why more data is still better

by van Rooij, Jeroen G J, Jhamai, Mila, Arp, Pascal P, Nouwens, Stephan C A, Verkerk, Marijn, Hofman, Albert, Ikram, M Arfan, Verkerk, Annemieke J, van Meurs, Joyce B J, Rivadeneira, Fernando, Uitterlinden, André G, Kraaij, Robert
Published in Eur J Hum Genet (2017)

Polymorphisms in the Sclerosteosis/van Buchem Disease Gene (SOST) Region Are Associated with Bone-Mineral Density in Elderly Whites

by Uitterlinden, Andre G., Arp, Pascal P., Paeper, Bryan W., Charmley, Patrick, Proll, Sean, Rivadeneira, Fernando, Fang, Yue, van Meurs, Joyce B. J., Britschgi, Theresa B., Latham, John A., Schatzman, Randall C., Pols, Huibert A. P., Brunkow, Mary E.
Published 2004

Intestinal microbiome composition and its relation to joint pain and inflammation

by Boer, Cindy G., Radjabzadeh, Djawad, Medina-Gomez, Carolina, Garmaeva, Sanzhima, Schiphof, Dieuwke, Arp, Pascal, Koet, Thomas, Kurilshikov, Alexander, Fu, Jingyuan, Ikram, M. Arfan, Bierma-Zeinstra, Sita, Uitterlinden, André G., Kraaij, Robert, Zhernakova, Alexandra, van Meurs, Joyce B. J.
Published in Nat Commun (2019)

Vitamin D Receptor Polymorphisms Are Associated with Reduced Esophageal Vitamin D Receptor Expression and Reduced Esophageal Adenocarcinoma Risk

by Janmaat, Vincent T, van de Winkel, Anouk, Peppelenbosch, Maikel P, Spaander, Manon C W, Uitterlinden, André G, Pourfarzad, Farzin, Tilanus, Hugo W, Rygiel, Agnieszka M, Moons, Leon M G, Arp, Pascal P, Krishnadath, Kausilia K, Kuipers, Ernst J, van der Laan, Luc J W
Published in Mol Med (2015)

Somatic TARDBP variants as a cause of semantic dementia

by van Rooij, Jeroen, Mol, Merel O, Melhem, Shamiram, van der Wal, Pelle, Arp, Pascal, Paron, Francesca, Donker Kaat, Laura, Seelaar, Harro, Miedema, Suzanne S M, Oshima, Takuya, Eggen, Bart J L, Uitterlinden, André, van Meurs, Joyce, van Kesteren, Ronald E, Smit, August B, Buratti, Emanuele, van Swieten, John C
Published in Brain (2020)

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study

by Reiling, Erwin, van Vliet-Ostaptchouk, Jana V, van 't Riet, Esther, van Haeften, Timon W, Arp, Pascal A, Hansen, Torben, Kremer, Dennis, Groenewoud, Marlous J, van Hove, Els C, Romijn, Johannes A, Smit, Jan W A, Nijpels, Giel, Heine, Robert J, Uitterlinden, André G, Pedersen, Oluf, Slagboom, P Eline, Maassen, Johannes A, Hofker, Marten H, 't Hart, Leen M, Dekker, Jacqueline M
Published 2009

Exome Sequencing Analysis Identifies Rare Variants in ATM and RPL8 That Are Associated With Shorter Telomere Length

by van der Spek, Ashley, Warner, Sophie C., Broer, Linda, Nelson, Christopher P., Vojinovic, Dina, Ahmad, Shahzad, Arp, Pascal P., Brouwer, Rutger W. W., Denniff, Matthew, van den Hout, Mirjam C. G. N., van Rooij, Jeroen G. J., Kraaij, Robert, van IJcken, Wilfred F. J., Samani, Nilesh J., Ikram, M. Arfan, Uitterlinden, André G., Codd, Veryan, Amin, Najaf, van Duijn, Cornelia M.
Published in Front Genet (2020)

Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene

by Kayser, Manfred, Liu, Fan, Janssens, A. Cecile J.W., Rivadeneira, Fernando, Lao, Oscar, van Duijn, Kate, Vermeulen, Mark, Arp, Pascal, Jhamai, Mila M., van IJcken, Wilfred F.J., den Dunnen, Johan T., Heath, Simon, Zelenika, Diana, Despriet, Dominiek D.G., Klaver, Caroline C.W., Vingerling, Johannes R., de Jong, Paulus T.V.M., Hofman, Albert, Aulchenko, Yurii S., Uitterlinden, Andre G., Oostra, Ben A., van Duijn, Cornelia M.
Published 2008

Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene

by Kayser, Manfred, Liu, Fan, Janssens, A. Cecile J.W., Rivadeneira, Fernando, Lao, Oscar, van Duijn, Kate, Vermeulen, Mark, Arp, Pascal, Jhamai, Mila M., van IJcken, Wilfred F.J., den Dunnen, Johan T., Heath, Simon, Zelenika, Diana, Despriet, Dominiek D.G., Klaver, Caroline C.W., Vingerling, Johannes R., de Jong, Paulus T.V.M., Hofman, Albert, Aulchenko, Yurii S., Uitterlinden, Andre G., Oostra, Ben A., van Duijn, Cornelia M.
Published 2008

Characteristics of de novo structural changes in the human genome

by Kloosterman, Wigard P., Francioli, Laurent C., Hormozdiari, Fereydoun, Marschall, Tobias, Hehir-Kwa, Jayne Y., Abdellaoui, Abdel, Lameijer, Eric-Wubbo, Moed, Matthijs H., Koval, Vyacheslav, Renkens, Ivo, van Roosmalen, Markus J., Arp, Pascal, Karssen, Lennart C., Coe, Bradley P., Handsaker, Robert E., Suchiman, Eka D., Cuppen, Edwin, Thung, Djie Tjwan, McVey, Mitch, Wendl, Michael C., Uitterlinden, André, van Duijn, Cornelia M., Swertz, Morris A., Wijmenga, Cisca, van Ommen, GertJan B., Slagboom, P. Eline, Boomsma, Dorret I., Schönhuth, Alexander, Eichler, Evan E., de Bakker, Paul I.W., Ye, Kai, Guryev, Victor
Published in Genome Res (2015)

Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size

by Soranzo, Nicole, Rivadeneira, Fernando, Chinappen-Horsley, Usha, Malkina, Ida, Richards, J. Brent, Hammond, Naomi, Stolk, Lisette, Nica, Alexandra, Inouye, Michael, Hofman, Albert, Stephens, Jonathan, Wheeler, Eleanor, Arp, Pascal, Gwilliam, Rhian, Jhamai, P. Mila, Potter, Simon, Chaney, Amy, Ghori, Mohammed J. R., Ravindrarajah, Radhi, Ermakov, Sergey, Estrada, Karol, Pols, Huibert A. P., Williams, Frances M., McArdle, Wendy L., van Meurs, Joyce B., Loos, Ruth J. F., Dermitzakis, Emmanouil T., Ahmadi, Kourosh R., Hart, Deborah J., Ouwehand, Willem H., Wareham, Nicholas J., Barroso, Inês, Sandhu, Manjinder S., Strachan, David P., Livshits, Gregory, Spector, Timothy D., Uitterlinden, André G., Deloukas, Panos
Published 2009

A Genome-Wide Association Study identifies a locus on chromosome 7q22 to influence susceptibility for osteoarthritis

by Kerkhof, Hanneke J.M., Lories, Rik J., Meulenbelt, Ingrid, Jonsdottir, Ingileif, Valdes, Ana M, Arp, Pascal, Ingvarsson, Thorvaldur, Jhamai, Mila, Jonsson, Helgi, Stolk, Lisette, Thorleifsson, Gudmar, Zhai, Guangju, Zhang, Feng, Zhu, Yanyan, van der Breggen, Ruud, Carr, Andrew, Doherty, Michael, Doherty, Sally, Felson, David T., Gonzalez, Antonio, Halldorsson, Bjarni V., Hart, Deborah J., Hauksson, Valdimar B., Hofman, Albert, Ioannidis, John P.A., Kloppenburg, Margreet, Lane, Nancy E., Loughlin, John, Luyten, Frank P., Nevitt, Michael C., Parimi, Neeta, Pols, Huibert A.P., van de Putte, Tom, Rivadeneira, Fernando, Slagboom, Eline P., Styrkársdóttir, Unnur, Tsezou, Aspasia, Zmuda, Joseph, Spector, Tim D., Stefansson, Kari, Uitterlinden, André G., van Meurs, Joyce B.J.
Published 2010

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

by Li, Chen, Stoma, Svetlana, Lotta, Luca A., Warner, Sophie, Albrecht, Eva, Allione, Alessandra, Arp, Pascal P., Broer, Linda, Buxton, Jessica L., Da Silva Couto Alves, Alexessander, Deelen, Joris, Fedko, Iryna O., Gordon, Scott D., Jiang, Tao, Karlsson, Robert, Kerrison, Nicola, Loe, Taylor K., Mangino, Massimo, Milaneschi, Yuri, Miraglio, Benjamin, Pervjakova, Natalia, Russo, Alessia, Surakka, Ida, van der Spek, Ashley, Verhoeven, Josine E., Amin, Najaf, Beekman, Marian, Blakemore, Alexandra I., Canzian, Federico, Hamby, Stephen E., Hottenga, Jouke-Jan, Jones, Peter D., Jousilahti, Pekka, Mägi, Reedik, Medland, Sarah E., Montgomery, Grant W., Nyholt, Dale R., Perola, Markus, Pietiläinen, Kirsi H., Salomaa, Veikko, Sillanpää, Elina, Suchiman, H. Eka, van Heemst, Diana, Willemsen, Gonneke, Agudo, Antonio, Boeing, Heiner, Boomsma, Dorret I., Chirlaque, Maria-Dolores, Fagherazzi, Guy, Ferrari, Pietro, Franks, Paul, Gieger, Christian, Eriksson, Johan Gunnar, Gunter, Marc, Hägg, Sara, Hovatta, Iiris, Imaz, Liher, Kaprio, Jaakko, Kaaks, Rudolf, Key, Timothy, Krogh, Vittorio, Martin, Nicholas G., Melander, Olle, Metspalu, Andres, Moreno, Concha, Onland-Moret, N. Charlotte, Nilsson, Peter, Ong, Ken K., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Pedersen, Nancy L., Penninx, Brenda W.J. H., Quirós, J. Ramón, Jarvelin, Marjo Riitta, Rodríguez-Barranco, Miguel, Scott, Robert A., Severi, Gianluca, Slagboom, P. Eline, Spector, Tim D., Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, Uitterlinden, André G., van der Schouw, Yvonne T., van Duijn, Cornelia M., Weiderpass, Elisabete, Denchi, Eros Lazzerini, Matullo, Giuseppe, Butterworth, Adam S., Danesh, John, Samani, Nilesh J., Wareham, Nicholas J., Nelson, Christopher P., Langenberg, Claudia, Codd, Veryan
Published in Am J Hum Genet (2020)

The transcriptional landscape of age in human peripheral blood

by Peters, Marjolein J., Joehanes, Roby, Pilling, Luke C., Schurmann, Claudia, Conneely, Karen N., Powell, Joseph, Reinmaa, Eva, Sutphin, George L., Zhernakova, Alexandra, Schramm, Katharina, Wilson, Yana A., Kobes, Sayuko, Tukiainen, Taru, Ramos, Yolande F., Göring, Harald H. H., Fornage, Myriam, Liu, Yongmei, Gharib, Sina A., Stranger, Barbara E., De Jager, Philip L., Aviv, Abraham, Levy, Daniel, Murabito, Joanne M., Munson, Peter J., Huan, Tianxiao, Hofman, Albert, Uitterlinden, André G., Rivadeneira, Fernando, van Rooij, Jeroen, Stolk, Lisette, Broer, Linda, Verbiest, Michael M. P. J., Jhamai, Mila, Arp, Pascal, Metspalu, Andres, Tserel, Liina, Milani, Lili, Samani, Nilesh J., Peterson, Pärt, Kasela, Silva, Codd, Veryan, Peters, Annette, Ward-Caviness, Cavin K., Herder, Christian, Waldenberger, Melanie, Roden, Michael, Singmann, Paula, Zeilinger, Sonja, Illig, Thomas, Homuth, Georg, Grabe, Hans-Jörgen, Völzke, Henry, Steil, Leif, Kocher, Thomas, Murray, Anna, Melzer, David, Yaghootkar, Hanieh, Bandinelli, Stefania, Moses, Eric K., Kent, Jack W., Curran, Joanne E., Johnson, Matthew P., Williams-Blangero, Sarah, Westra, Harm-Jan, McRae, Allan F., Smith, Jennifer A., Kardia, Sharon L. R., Hovatta, Iiris, Perola, Markus, Ripatti, Samuli, Salomaa, Veikko, Henders, Anjali K., Martin, Nicholas G., Smith, Alicia K., Mehta, Divya, Binder, Elisabeth B., Nylocks, K Maria, Kennedy, Elizabeth M., Klengel, Torsten, Ding, Jingzhong, Suchy-Dicey, Astrid M., Enquobahrie, Daniel A., Brody, Jennifer, Rotter, Jerome I., Chen, Yii-Der I., Houwing-Duistermaat, Jeanine, Kloppenburg, Margreet, Slagboom, P. Eline, Helmer, Quinta, den Hollander, Wouter, Bean, Shannon, Raj, Towfique, Bakhshi, Noman, Wang, Qiao Ping, Oyston, Lisa J., Psaty, Bruce M., Tracy, Russell P., Montgomery, Grant W., Turner, Stephen T., Blangero, John, Meulenbelt, Ingrid, Ressler, Kerry J., Yang, Jian, Franke, Lude, Kettunen, Johannes, Visscher, Peter M., Neely, G. Gregory, Korstanje, Ron, Hanson, Robert L., Prokisch, Holger, Ferrucci, Luigi, Esko, Tonu, Teumer, Alexander, van Meurs, Joyce B. J., Johnson, Andrew D.
Published in Nat Commun (2015)

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

by Zheng, Hou-Feng, Forgetta, Vincenzo, Hsu, Yi-Hsiang, Estrada, Karol, Rosello-Diez, Alberto, Leo, Paul J, Dahia, Chitra L, Park-Min, Kyung Hyun, Tobias, Jonathan H, Kooperberg, Charles, Kleinman, Aaron, Styrkarsdottir, Unnur, Liu, Ching-Ti, Uggla, Charlotta, Evans, Daniel S, Nielson, Carrie M, Walter, Klaudia, Pettersson-Kymmer, Ulrika, McCarthy, Shane, Eriksson, Joel, Kwan, Tony, Jhamai, Mila, Trajanoska, Katerina, Memari, Yasin, Min, Josine, Huang, Jie, Danecek, Petr, Wilmot, Beth, Li, Rui, Chou, Wen-Chi, Mokry, Lauren E, Moayyeri, Alireza, Claussnitzer, Melina, Cheng, Chia-Ho, Cheung, Warren, Medina-Gómez, Carolina, Ge, Bing, Chen, Shu-Huang, Choi, Kwangbom, Oei, Ling, Fraser, James, Kraaij, Robert, Hibbs, Matthew A, Gregson, Celia L, Paquette, Denis, Hofman, Albert, Wibom, Carl, Tranah, Gregory J, Marshall, Mhairi, Gardiner, Brooke B, Cremin, Katie, Auer, Paul, Hsu, Li, Ring, Sue, Tung, Joyce Y, Thorleifsson, Gudmar, Enneman, Anke W, van Schoor, Natasja M, de Groot, Lisette C.P.G.M., van der Velde, Nathalie, Melin, Beatrice, Kemp, John P, Christiansen, Claus, Sayers, Adrian, Zhou, Yanhua, Calderari, Sophie, van Rooij, Jeroen, Carlson, Chris, Peters, Ulrike, Berlivet, Soizik, Dostie, Josée, Uitterlinden, Andre G, Williams, Stephen R., Farber, Charles, Grinberg, Daniel, LaCroix, Andrea Z, Haessler, Jeff, Chasman, Daniel I, Giulianini, Franco, Rose, Lynda M, Ridker, Paul M, Eisman, John A, Nguyen, Tuan V, Center, Jacqueline R, Nogues, Xavier, Garcia-Giralt, Natalia, Launer, Lenore L, Gudnason, Vilmunder, Mellström, Dan, Vandenput, Liesbeth, Karlsson, Magnus K, Ljunggren, Östen, Svensson, Olle, Hallmans, Göran, Rousseau, François, Giroux, Sylvie, Bussière, Johanne, Arp, Pascal P, Koromani, Fjorda, Prince, Richard L, Lewis, Joshua R, Langdahl, Bente L, Hermann, A Pernille, Jensen, Jens-Erik B, Kaptoge, Stephen, Khaw, Kay-Tee, Reeve, Jonathan, Formosa, Melissa M, Xuereb-Anastasi, Angela, Åkesson, Kristina, McGuigan, Fiona E, Garg, Gaurav, Olmos, Jose M, Zarrabeitia, Maria T, Riancho, Jose A, Ralston, Stuart H, Alonso, Nerea, Jiang, Xi, Goltzman, David, Pastinen, Tomi, Grundberg, Elin, Gauguier, Dominique, Orwoll, Eric S, Karasik, David, Davey-Smith, George, Smith, Albert V, Siggeirsdottir, Kristin, Harris, Tamara B, Zillikens, M Carola, van Meurs, Joyce BJ, Thorsteinsdottir, Unnur, Maurano, Matthew T, Timpson, Nicholas J, Soranzo, Nicole, Durbin, Richard, Wilson, Scott G, Ntzani, Evangelia E, Brown, Matthew A, Stefansson, Kari, Hinds, David A, Spector, Tim, Cupples, L Adrienne, Ohlsson, Claes, Greenwood, Celia MT, Jackson, Rebecca D, Rowe, David W, Loomis, Cynthia A, Evans, David M, Ackert-Bicknell, Cheryl L, Joyner, Alexandra L, Duncan, Emma L, Kiel, Douglas P, Rivadeneira, Fernando, Richards, J Brent
Published in Nature (2015)