A Genome-Wide Association Study identifies a locus on chromosome 7q22 to influence susceptibility for osteoarthritis

To identify genes involved in osteoarthritis (OA), the most prevalent form of joint disease, we performed a genome-wide association study (GWAS) in which we tested 500,510 Single Nucelotide Polymorphisms (SNPs) in 1341 OA cases and 3496 Dutch Caucasian controls. SNPs associated with at least two OA-...

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Main Authors: Kerkhof, Hanneke J.M., Lories, Rik J., Meulenbelt, Ingrid, Jonsdottir, Ingileif, Valdes, Ana M, Arp, Pascal, Ingvarsson, Thorvaldur, Jhamai, Mila, Jonsson, Helgi, Stolk, Lisette, Thorleifsson, Gudmar, Zhai, Guangju, Zhang, Feng, Zhu, Yanyan, van der Breggen, Ruud, Carr, Andrew, Doherty, Michael, Doherty, Sally, Felson, David T., Gonzalez, Antonio, Halldorsson, Bjarni V., Hart, Deborah J., Hauksson, Valdimar B., Hofman, Albert, Ioannidis, John P.A., Kloppenburg, Margreet, Lane, Nancy E., Loughlin, John, Luyten, Frank P., Nevitt, Michael C., Parimi, Neeta, Pols, Huibert A.P., van de Putte, Tom, Rivadeneira, Fernando, Slagboom, Eline P., Styrkársdóttir, Unnur, Tsezou, Aspasia, Zmuda, Joseph, Spector, Tim D., Stefansson, Kari, Uitterlinden, André G., van Meurs, Joyce B.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354739/
https://ncbi.nlm.nih.gov/pubmed/20112360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27184
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