Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells

Por Taylor, Jackson R., Lehmann, Brian D., Chappell, William H., Abrams, Stephen L., Steelman, Linda S., McCubrey, McCubrey
Publicado em 2011

p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3

Por Chappell, William H., Lehmann, Brian D., Terrian, David M., Abrams, Stephen L., Steelman, Linda S., McCubrey, James A.
Publicado em 2012

The therapeutic potential of mTOR inhibitors in breast cancer

Por Steelman, Linda S., Martelli, Alberto M., Cocco, Lucio, Libra, Massimo, Nicoletti, Ferdinando, Abrams, Stephen L., McCubrey, James A.
Publicado no Br J Clin Pharmacol (2016)

Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells

Por Sokolosky, Melissa, Chappell, William H, Stadelman, Kristin, Abrams, Stephen L, Davis, Nicole M, Steelman, Linda S, McCubrey, James A
Publicado em 2014

Targeting Signal Transduction Pathways to Eliminate Chemotherapeutic Drug Resistance and Cancer Stem Cells

Por McCubrey, James A., Abrams, Stephen L., Stadelman, Kristin, Chappell, William H., LaHair, Michelle, Franklin, Richard F., Steelman, Linda S.
Publicado em 2009

Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy

Por Abrams, Stephen L., Steelman, Linda S., Shelton, John G., Chappell, William, Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A.
Publicado em 2010

Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs

Por Steelman, Linda S., Abrams, Stephen L., Shelton, John G., Chappell, William H., Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A.
Publicado em 2010

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity

Por Chappell, William H., Abrams, Stephen L., Montalto, Giuseppe, Cervello, Melchiorre, Martelli, Alberto M., Candido, Saverio, Libra, Massimo, Polesel, Jerry, Talamini, Renato, Arlinghaus, Ralph, Steelman, Linda S., McCubrey, James A.
Publicado em 2012

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

Por Abrams, Stephen L., Steelman, Linda S., Shelton, John G., Wong, Ellis W.T., Chappell, William H., Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A.
Publicado em 2010

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy

Por Sokolosky, Melissa L., Stadelman, Kristin M., Chappell, William H., Abrams, Stephen L., Martelli, Alberto M., Stivala, Franca, Libra, Massimo, Nicoletti, Ferdinando, Drobot, Lyudmyla B., Franklin, Richard A., Steelman, Linda S., McCubrey, James A.
Publicado em 2011

Involvement of Akt and mTOR in chemotherapeutic and hormonal-based drug resistance and response to radiation in breast cancer cells

Por Steelman, Linda S, Navolanic, Patrick, Chappell, William H, Abrams, Stephen L, Wong, Ellis WT, Martelli, Alberto M, Cocco, Lucio, Stivala, Franca, Libra, Massimo, Nicoletti, Ferdinando, Drobot, Lyudmyla B, Franklin, Richard A, McCubrey, James A
Publicado em 2011

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

Por Chappell, William H., Abrams, Stephen L., Franklin, Richard A., LaHair, Michelle M., Montalto, Giuseppe, Cervello, Melchiorre, Martelli, Alberto M., Nicoletti, Ferdinando, Candido, Saverio, Libra, Massimo, Polesel, Jerry, Talamini, Renato, Milella, Michele, Tafuri, Agostino, Steelman, Linda S., McCubrey, James A.
Publicado em 2012

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells

Por McCubrey, James A., Fitzgerald, Timothy L., Yang, Li V., Lertpiriyapong, Kvin, Steelman, Linda S., Abrams, Stephen L., Montalto, Giuseppe, Cervello, Melchiorre, Neri, Luca M., Cocco, Lucio, Martelli, Alberto M., Laidler, Piotr, Dulińska-Litewka, Joanna, Rakus, Dariusz, Gizak, Agnieszka, Nicoletti, Ferdinando, Falzone, Luca, Candido, Saverio, Libra, Massimo
Publicado no Oncotarget (2016)

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response

Por McCubrey, James A., Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Montalto, Giuseppe, Cervello, Melchiorre, Nicoletti, Ferdinando, Fagone, Paolo, Malaponte, Grazia, Mazzarino, Maria C., Candido, Saverio, Libra, Massimo, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Milella, Michele, Tafuri, Agostino, Cocco, Lucio, Evangelisti, Camilla, Chiarini, Francesca, Martelli, Alberto M.
Publicado em 2012

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

Por McCubrey, James A., Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Franklin, Richard A., Montalto, Giuseppe, Cervello, Melchiorre, Libra, Massimo, Candido, Saverio, Malaponte, Grazia, Mazzarino, Maria C., Fagone, Paolo, Nicoletti, Ferdinando, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Milella, Michele, Tafuri, Agostino, Chiarini, Francesca, Evangelisti, Camilla, Cocco, Lucio, Martelli, Alberto M.
Publicado em 2012

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Por Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Kempf, C. Ruth, Long, Jacquelyn, Laidler, Piotr, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Stivala, Franca, Mazzarino, Maria C., Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Nicoletti, Ferdinando, Libra, Massimo, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Bäsecke, Jörg, Cocco, Lucio, Evangelisti, Camilla, Martelli, Alberto M., Montalto, Giuseppe, Cervello, Melchiorre, McCubrey, James A.
Publicado em 2011

ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY

Por McCubrey, James A., Sokolosky, Melissa L., Lehmann, Brian D., Taylor, Jackson R., Navolanic, Patrick M., Chappell, William H., Abrams, Stephen L., Stadelman, Kristin M., Wong, Ellis WT, Misaghian, Negin, Horn, Stefan, Bäsecke, Jörg, Libra, Massimo, Stivala, Franca, Ligresti, Giovanni, Tafuri, Agostino, Milella, Michele, Zarzycki, Marek, Dzugaj, Andrzej, Chiarini, Francesca, Evangelisti, Camilla, Martelli, Alberto M., Terrian, David M., Franklin, Richard A., Steelman, Linda S.
Publicado em 2008

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

Por Chappell, William H., Steelman, Linda S., Long, Jacquelyn M., Kempf, Ruth C., Abrams, Stephen L., Franklin, Richard A., Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Mazzarino, Maria C., Nicoletti, Ferdinando, Libra, Massimo, Maksimovic-Ivanic, Danijela, Mijatovic, Sanja, Montalto, Giuseppe, Cervello, Melchiorre, Laidler, Piotr, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Evangelisti, Camilla, Cocco, Lucio, Martelli, Alberto M., McCubrey, James A.
Publicado em 2011

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

Por Davis, Nicole M., Sokolosky, Melissa, Stadelman, Kristin, Abrams, Stephen L., Libra, Massimo, Candido, Saverio, Nicoletti, Ferdinando, Polesel, Jerry, Maestro, Roberta, D’Assoro, Antonino, Drobot, Lyudmyla, Rakus, Dariusz, Gizak, Agnieszka, Laidler, Piotr, Dulińska-Litewka, Joanna, Basecke, Joerg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Montalto, Giuseppe, Cervello, Melchiorre, Fitzgerald, Timothy L., Demidenko, Zoya N., Martelli, Alberto M., Cocco, Lucio, Steelman, Linda S., McCubrey, James A.
Publicado em 2014

Advances in Targeting Signal Transduction Pathways

Por McCubrey, James A., Steelman, Linda S., Chappell, William H., Sun, Lin, Davis, Nicole M., Abrams, Stephen L., Franklin, Richard A., Cocco, Lucio, Evangelisti, Camilla, Chiarini, Francesca, Martelli, Alberto M., Libra, Massimo, Candido, Saverio, Ligresti, Giovanni, Malaponte, Grazia, Mazzarino, Maria C., Fagone, Paolo, Donia, Marco, Nicoletti, Ferdinando, Polesel, Jerry, Talamini, Renato, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Milella, Michele, Tafuri, Agostino, Dulińska-Litewka, Joanna, Laidler, Piotr, D'Assoro, Antonio B., Drobot, Lyudmyla, Umezawa, Kazuo, Montalto, Giuseppe, Cervello, Melchiorre, Demidenko, Zoya N.
Publicado em 2012