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The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

The effects of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways on proliferation, drug resistance, prevention of apoptosis and sensitivity to signal transduction inhibitors were examined in FL/ΔAkt-1:ER*(Myr(+)) + ΔRaf-1:AR cells which are conditionally-transformed to grow in response to Ra...

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מידע ביבליוגרפי
Main Authors: Abrams, Stephen L., Steelman, Linda S., Shelton, John G., Wong, Ellis W.T., Chappell, William H., Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A.
פורמט: Artigo
שפה:Inglês
יצא לאור: Landes Bioscience 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781182/
https://ncbi.nlm.nih.gov/pubmed/20436278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.9.11483
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