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The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy
The effects of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways on proliferation, drug resistance, prevention of apoptosis and sensitivity to signal transduction inhibitors were examined in FL/ΔAkt-1:ER*(Myr(+)) + ΔRaf-1:AR cells which are conditionally-transformed to grow in response to Ra...
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Main Authors: | , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Landes Bioscience
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3781182/ https://ncbi.nlm.nih.gov/pubmed/20436278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.9.11483 |
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