Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs

The effects of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways on cell cycle progression, gene expression, prevention of apoptosis and sensitivity to chemotherapeutic drugs were examined in FL/ΔAkt-1:ER*(Myr(+)) + ΔRaf-1:AR cells which are conditionally-transformed to grow in response to R...

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Detalhes bibliográficos
Main Authors: Steelman, Linda S., Abrams, Stephen L., Shelton, John G., Chappell, William H., Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781180/
https://ncbi.nlm.nih.gov/pubmed/20372086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.8.11487
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