Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines

Background: TP53 plays critical roles in sensitivity to chemotherapy, and aging. Collagen is very important in aging. The molecular structure and biochemical properties of collagen changes during aging. The discoidin domain receptor (DDR1) is regulated in part by collagen. Elucidating the links betw...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Chappell, William H., Candido, Saverio, Abrams, Stephen L., Akula, Shaw M., Steelman, Linda S., Martelli, Alberto M., Ratti, Stefano, Cocco, Lucio, Cervello, Melchiorre, Montalto, Giuseppe, Nicoletti, Ferdinando, Libra, Massimo, McCubrey, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346063/
https://ncbi.nlm.nih.gov/pubmed/32492656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103377
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