The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

The effects of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways on proliferation, drug resistance, prevention of apoptosis and sensitivity to signal transduction inhibitors were examined in FL/ΔAkt-1:ER*(Myr(+)) + ΔRaf-1:AR cells which are conditionally-transformed to grow in response to Ra...

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Bibliographische Detailangaben
Hauptverfasser: Abrams, Stephen L., Steelman, Linda S., Shelton, John G., Wong, Ellis W.T., Chappell, William H., Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2010
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Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781182/
https://ncbi.nlm.nih.gov/pubmed/20436278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.9.11483
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