ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY

The PI3K/PTEN/Akt/mTOR pathway plays critical roles in the regulation of cell growth. The effects of this pathway on drug resistance and cellular senescence of breast cancer cells has been a focus of our laboratory. Introduction of activated Akt or mutant PTEN constructs which lack lipid phosphatase...

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Main Authors: McCubrey, James A., Sokolosky, Melissa L., Lehmann, Brian D., Taylor, Jackson R., Navolanic, Patrick M., Chappell, William H., Abrams, Stephen L., Stadelman, Kristin M., Wong, Ellis WT, Misaghian, Negin, Horn, Stefan, Bäsecke, Jörg, Libra, Massimo, Stivala, Franca, Ligresti, Giovanni, Tafuri, Agostino, Milella, Michele, Zarzycki, Marek, Dzugaj, Andrzej, Chiarini, Francesca, Evangelisti, Camilla, Martelli, Alberto M., Terrian, David M., Franklin, Richard A., Steelman, Linda S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583357/
https://ncbi.nlm.nih.gov/pubmed/18423407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.advenzreg.2008.02.006
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