Suppression of PTEN Function Increases Breast Cancer Chemotherapeutic Drug Resistance while Conferring Sensitivity to mTOR Inhibitors

Ectopic expression of mutant forms of PTEN lacking lipid (G129E) or lipid and protein (C124S) phosphatase activity decreased sensitivity of MCF-7 breast cancer cells, which have wild-type PTEN, to doxorubicin and increased sensitivity to the mTOR inhibitor rapamycin. Cells transfected with a mutant...

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Autors principals: Steelman, Linda S., Navolanic, Patrick M., Sokolosky, Melissa L., Taylor, Jackson R., Lehmann, Brian D., Chappell, William H., Abrams, Steven L., Wong, Ellis W.T., Stadelman, Kristin M., Terrian, David M., Leslie, Nick R., Martelli, C. Alberto M., Stivala, Franca, Libra, Massimo, Franklin, Richard A., McCubrey, James A.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836277/
https://ncbi.nlm.nih.gov/pubmed/18332865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.49
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