Resultados da pesquisa - ((drug (dosev OR dosed)) or (drug dose)) (devel or level) ther*

101

Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers

Por Gillen, Michael, Valdez, Shakti, Zhou, Dongmei, Kerr, Bradley, Lee, Caroline A, Shen, Zancong
Publicado no Drug Des Devel Ther (2016)

“... serum uric acid (sUA) levels with an XOI alone. Most people with gout have chronic kidney disease...”
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102

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Adenosine A(2A) receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

Por da Silva, Jaqueline S, Gabriel-Costa, Daniele, Sudo, Roberto T, Wang, Hao, Groban, Leanne, Ferraz, Emanuele B, Nascimento, José Hamilton M, Fraga, Carlos Alberto M, Barreiro, Eliezer J, Zapata-Sudo, Gisele
Publicado no Drug Des Devel Ther (2017)

“... recovery in a dose-dependent manner after treatment with LASSBio-294. Exercise intolerance observed...”
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103

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The mechanism of botulinum A on Raynaud syndrome

Por Zhou, Yanwen, Liu, Ying, Hao, Yunhua, Feng, Ya, Pan, Lizhen, Liu, Wuchao, Li, Bing, Xiao, Libin, Jin, Lingjing, Nie, Zhiyu
Publicado no Drug Des Devel Ther (2018)

“... of norepinephrine (NE), protein level changes and related receptors on cultured rat superior cervical ganglia...”
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104

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Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

Por Lin, Ji-Fan, Lin, Yi-Chia, Tsai, Te-Fu, Chen, Hung-En, Chou, Kuang-Yu, Hwang, Thomas I-Sheng
Publicado no Drug Des Devel Ther (2017)

“... cancer; and a high basal level of autophagy has been demonstrated in human bladder tumors. Therefore...”
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105

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Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4

Por Runtuwene, Joshua, Cheng, Kai-Chun, Asakawa, Akihiro, Amitani, Haruka, Amitani, Marie, Morinaga, Akinori, Takimoto, Yoshiyuki, Kairupan, Bernabas Harold Ralph, Inui, Akio
Publicado no Drug Des Devel Ther (2016)

“... assessment for insulin resistance. Additionally, the protein expression levels of PEPCK and GLUT4 were...”
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106

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Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study

Por Kono, Yasushi, Fukuda, Shota, Shimada, Kenei, Nakanishi, Koki, Otsuka, Kenichiro, Kubo, Tomoichiro, Jissho, Satoshi, Taguchi, Haruyuki, Yoshikawa, Junichi, Yoshiyama, Minoru
Publicado em 2013

“... = 0.4). No significant changes were observed at 2 hours in serum cholesterol levels in each group...”
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107

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Comparison of neurotoxic potency between a novel chinbotulinumtoxinA with onabotulinumtoxinA, incobotulinumtoxinA and lanbotulinumtoxinA in rats

Por Feng, Ya, Liu, Wuchao, Pan, Lizhen, Jiang, Cong, Zhang, Chengxi, Lu, Yuxuan, Nie, Zhiyu, Jin, Lingjing
Publicado no Drug Des Devel Ther (2017)

“... to the other three products at the dose of 0.5 U. However, there was no difference between the four toxins when...”
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108

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Positive effects on hematological and biochemical imbalances in patients with metastatic breast cancer stage IV, of BP-C1, a new anticancer substance

Por Lindkær-Jensen, Steen, Larsen, Stig, Habib-Lindkær-Jensen, Nina, Fagertun, Hans E
Publicado no Drug Des Devel Ther (2015)

“... injections of BP-C1 for 32 days. Study I was performed as an open, nonrandomized, Phase I dose–response...”
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109

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Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells

Por Chan-on, Waraporn, Huyen, Nguyen Thi Bich, Songtawee, Napat, Suwanjang, Wilasinee, Prachayasittikul, Supaluk, Prachayasittikul, Virapong
Publicado no Drug Des Devel Ther (2015)

“...) and nitroxoline (NQ), represent a new class of anticancer drug. However, their efficacy and underlying mechanisms...”
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110

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Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Por Kocdor, Hilal, Ates, Halil, Aydin, Suleyman, Cehreli, Ruksan, Soyarat, Firat, Kemanli, Pinar, Harmanci, Duygu, Cengiz, Hakan, Kocdor, Mehmet Ali
Publicado no Drug Des Devel Ther (2015)

“... cells to cytotoxic agents depending on the p53 status. Therefore, zinc supplementation may show...”
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111

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Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma

Por Kwak, Tae Won, Shin, Hee Jae, Jeong, Young-Il, Han, Myoung-Eun, Oh, Sae-Ock, Kim, Hyun-Jung, Kim, Do Hyung, Kang, Dae Hwan
Publicado no Drug Des Devel Ther (2015)

“..., and expression of various protein levels. A liver metastasis model was prepared by splenic injection of HuCC-T1...”
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112

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Effects of a novel ACE inhibitor, 3-(3-thienyl)-l-alanyl-ornithyl-proline, on endothelial vasodilation and hepatotoxicity in l-NAME-induced hypertensive rats

Por Seth, Mahesh Kumar, Hussain, M Ejaz, Pasha, Santosh, Fahim, Mohammad
Publicado no Drug Des Devel Ther (2016)

“...-NAME model, but TOP showed better restoration of NO and normal levels of angiotensin-converting enzyme...”
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113

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Linagliptin: from bench to bedside

Por Doupis, John
Publicado em 2014

“... reduction, typically ranging from 0.6% to 0.8% depending on baseline levels. In addition...”
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114

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Effects of metformin extended release compared to immediate release formula on glycemic control and glycemic variability in patients with type 2 diabetes

Por Derosa, Giuseppe, D’Angelo, Angela, Romano, Davide, Maffioli, Pamela
Publicado no Drug Des Devel Ther (2017)

“... randomized to metformin IR or metformin XR for a period of 6 months at the maximum tolerated dose...”
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115

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The role of IL-1 inhibition in systemic juvenile idiopathic arthritis: current status and future perspectives

Por Toplak, Nataša, Blazina, Štefan, Avčin, Tadej
Publicado no Drug Des Devel Ther (2018)

“... of biologic therapy, treatment of SJIA was primarily based on long-term treatment with high doses...”
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116

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Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFκB pathways in cholangiocarcinoma cells

Por Ke, Fayong, Wang, Zheng, Song, Xiaoling, Ma, Qiang, Hu, Yunping, Jiang, Lin, Zhang, Yijian, Liu, Yingbin, Zhang, Yong, Gong, Wei
Publicado no Drug Des Devel Ther (2017)

“... inhibition in HCCC-9810 and RBE cells in a dose-dependent manner. Intraperitoneal injection of CTS (0, 10...”
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117

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Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway

Por Wang, Juan, Wang, Handong, Sun, Kangjian, Wang, Xiaoliang, Pan, Hao, Zhu, Jianhong, Ji, Xiangjun, Li, Xiang
Publicado no Drug Des Devel Ther (2018)

“... the proliferation, migration, and invasion capacity of glioblastoma cells in dose- and time-dependent manners...”
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118

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Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Por Donejko, Magdalena, Przylipiak, Andrzej, Rysiak, Edyta, Miltyk, Wojciech, Galicka, Elżbieta, Przylipiak, Jerzy, Zaręba, Ilona, Surazynski, Arkadiusz
Publicado no Drug Des Devel Ther (2015)

“... activity, and matrix metalloproteinases (MMP-9 and MMP-2). RESULTS: Ethanol in a dose-dependent manner lead...”
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119

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Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials

Por Xu, Zhixing, Fan, Changchun, Zhao, Xuechun, Tao, Hairong
Publicado no Drug Des Devel Ther (2016)

“... suppressed the NTX level to a greater degree (test for overall effectZ=3.82,P<0.0001). ELD was also found...”
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120

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Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

Por Tian, Nianxiu, Gao, Yanbin, Wang, Xiaolei, Wu, Xiaoming, Zou, Dawei, Zhu, Zhiyao, Han, ZheJi, Wang, Tao, Shi, Yimin
Publicado no Drug Des Devel Ther (2018)

“... with emodin at dose of 40 and 80 mg/kg/day for 8 weeks. Urine albumin, serum creatinine, blood urea nitrogen...”
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