Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells

PURPOSE: Fork head box M1 (FoxM1) is an oncogenic transcription factor frequently elevated in numerous cancers, including cholangiocarcinoma (CCA). A growing body of evidence documents its diverse functions contributing to tumorigenesis and cancer progression. As such, discovery of agents that can t...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Chan-on, Waraporn, Huyen, Nguyen Thi Bich, Songtawee, Napat, Suwanjang, Wilasinee, Prachayasittikul, Supaluk, Prachayasittikul, Virapong
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396583/
https://ncbi.nlm.nih.gov/pubmed/25897210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S79313
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