Resultados da pesquisa - (( j nat com ((can now) OR (can new)) ) OR ((( j nagy clamp a now ) OR ( j ed con plan now ))))*

Pesquisas alternativas:
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plan » play (Expandir a Pesquisa)

1

New Ligands for Nickel Catalysis from Diverse Pharmaceutical Heterocycle Libraries

New Ligands for Nickel Catalysis from Diverse Pharmaceutical Heterocycle Libraries

Por Hansen, Eric C., Pedro, Dylan J., Wotal, Alexander C., Gower, Nicholas J., Nelson, Jade D., Caron, Stephane, Weix, Daniel J.
Publicado no Nat Chem (2016)

“... is anticipated to be time consuming. Here we show that this process can be dramatically accelerated by mining a...”
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2

Discovery of new GPCR ligands to illuminate new biology

Discovery of new GPCR ligands to illuminate new biology

Por Roth, Bryan L, Irwin, John J, Shoichet, Brian K
Publicado no Nat Chem Biol (2017)

“... over others. The ligands that emerge are often chemically novel, which can lead to new biological...”
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3

Membrane-anchoring stabilizes and favors secretion of New Delhi Metallo-β-lactamase

Membrane-anchoring stabilizes and favors secretion of New Delhi Metallo-β-lactamase

Por González, Lisandro J., Bahr, Guillermo, Nakashige, Toshiki G., Nolan, Elizabeth M., Bonomo, Robert A., Vila, Alejandro J.
Publicado no Nat Chem Biol (2016)

“... and the bla(NDM) gene. We show that protein export into OMVs can be targeted, providing possibilities of new...”
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4

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

Por Liu, Jimmy Z, Almarri, Mohamed A, Gaffney, Daniel J, Mells, George F, Jostins, Luke, Cordell, Heather J, Ducker, Samantha J, Day, Darren B, Heneghan, Michael A, Neuberger, James M., Donaldson, Peter T, Bathgate, Andrew J, Burroughs, Andrew, Davies, Mervyn H, Jones, David E, Alexander, Graeme J, Barrett, Jeffrey C, Sandford, Richard N, Anderson, Carl A
Publicado em 2012

“.... The most associated variant at 19p12 is a low-frequency non-synonymous SNP in TYK2, further implicating JAK...”
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5

Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription

Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription

Por Werner, Michael S., Sullivan, Matthew A., Shah, Rohan N., Nadadur, Rangarajan D., Grzybowski, Adrian T., Galat, Vasiliy, Moskowitz, Ivan P., Ruthenburg, Alexander J.
Publicado no Nat Struct Mol Biol (2017)

“...We recently described a new class of long noncoding RNA defined by especially tight chromatin...”
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6

Designer vaccine nanodiscs for personalized cancer immunotherapy

Designer vaccine nanodiscs for personalized cancer immunotherapy

Por Kuai, Rui, Ochyl, Lukasz J., Bahjat, Keith S., Schwendeman, Anna, Moon, James J.
Publicado no Nat Mater (2016)

“... therapy. These findings represent a new powerful approach for cancer immunotherapy and suggest a general...”
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7

Closed-loop optogenetic control of thalamus as a new tool to interrupt seizures after cortical injury

Closed-loop optogenetic control of thalamus as a new tool to interrupt seizures after cortical injury

Por Paz, Jeanne T., Davidson, Thomas J., Frechette, Eric S., Delord, Bruno, Parada, Isabel, Peng, Kathy, Deisseroth, Karl, Huguenard, John R.
Publicado em 2012

“... consequences can result from post-injury local reorganization of cortical circuits. For example, epilepsy is a...”
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8

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics

Por Rose, John C., Stephany, Jason J., Valente, William J., Trevillian, Bridget M., Dang, Ha V., Bielas, Jason H., Maly, Dustin J., Fowler, Douglas M.
Publicado no Nat Methods (2017)

“... developed two new tools. The first, chemically inducible Cas9 (ciCas9), is a rapidly-activated, single...”
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9

Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA

Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA

Por Lam, Bianca J., Joyce, Gerald F.
Publicado em 2009

“... in a sample. This process is analogous to quantitative PCR (qPCR), but can be generalized to a wide...”
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10

dsRNAs containing multiple IU pairs are sufficient to suppress interferon induction and apoptosis

dsRNAs containing multiple IU pairs are sufficient to suppress interferon induction and apoptosis

Por Vitali, Patrice, Scadden, A.D.J
Publicado em 2010

“... in various cellular functions, we now provide evidence suggesting a novel role. We show that IU-dsRNA...”
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11

MYC Suppresses Cancer Metastasis by Direct Transcriptional Silencing of αv and β3 Integrin Subunits

MYC Suppresses Cancer Metastasis by Direct Transcriptional Silencing of αv and β3 Integrin Subunits

Por Liu, Hong, Radisky, Derek C., Yang, Dun, Xu, Ren, Radisky, Evette S., Bissell, Mina J., Bishop, J. Michael
Publicado em 2012

“... oncogene can also act as a suppressor of cell motility, invasiveness and metastasis. Overexpression of MYC...”
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12

Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection

Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection

Por MacKay, J. Andrew, Chen, Mingnan, McDaniel, Jonathan R., Liu, Wenge, Simnick, Andrew J., Chilkoti, Ashutosh
Publicado em 2009

“...New strategies to self-assemble biocompatible materials into nanoscale, drug-loaded packages...”
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13

Singlet oxygen Triplet Energy Transfer based imaging technology for mapping protein-protein proximity in intact cells

Singlet oxygen Triplet Energy Transfer based imaging technology for mapping protein-protein proximity in intact cells

Por To, Tsz-Leung, Fadul, Michael J., Shu, Xiaokun
Publicado em 2014

“... the theoretical development and experimental demonstration of a new fluorescence imaging technology with a...”
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14

Self-luminescing BRET-FRET near infrared dots for in vivo lymph node mapping and tumor imaging

Self-luminescing BRET-FRET near infrared dots for in vivo lymph node mapping and tumor imaging

Por Xiong, Liqin, Shuhendler, Adam J., Rao, Jianghong
Publicado em 2012

“... can tackled by using imaging probes that emit in the near-infrared (NIR) wavelength range. Here we...”
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15

An optimized optogenetic clustering tool for probing protein interaction and function

An optimized optogenetic clustering tool for probing protein interaction and function

Por Taslimi, Amir, Vrana, Justin D., Chen, Daniel, Borinskaya, Sofya, Mayer, Bruce J., Kennedy, Matthew J., Tucker, Chandra L.
Publicado em 2014

“..., allowing spatiotemporal control of cellular processes with light. Here we report the development of a new...”
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16

Rescue of hearing and vestibular function in a mouse model of human deafness

Rescue of hearing and vestibular function in a mouse model of human deafness

Por Lentz, Jennifer J., Jodelka, Francine M., Hinrich, Anthony J., McCaffrey, Kate E., Farris, Hamilton E., Spalitta, Mathew J., Bazan, Nicolas G., Duelli, Dominik M., Rigo, Frank, Hastings, Michelle L.
Publicado em 2013

“... that hearing and vestibular function can be rescued in a mouse model of human hereditary deafness. An antisense...”
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17

A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease

A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease

Por O’Brien, Valerie P., Hannan, Thomas J., Yu, Lu, Livny, Jonathan, Roberson, Elisha D. O., Schwartz, Drew J., Souza, Spenser, Mendelsohn, Cathy L., Colonna, Marco, Lewis, Amanda L., Hultgren, Scott J.
Publicado no Nat Microbiol (2016)

“... is often a significant risk factor for developing new infections. For urinary tract infection (UTI), a...”
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18

Label-free in vivo imaging of myelinated axons in
health and disease with spectral confocal reflectance microscopy

Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy

Por Schain, Aaron J., Hill, Robert A., Grutzendler, Jaime
Publicado em 2014

“...We report a new technique for high-resolution in vivo imaging of myelinated axons in the brain...”
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19

A multi-phase transitioning peptide hydrogel for suturing ultra-small vessels

A multi-phase transitioning peptide hydrogel for suturing ultra-small vessels

Por Smith, Daniel J., Brat, Gabriel A., Medina, Scott H., Tong, Dedi, Huang, Yong, Grahammer, Johanna, Furtmüller, Georg J., Oh, Byoung Chol, Nagy-Smith, Katelyn J., Walczak, Piotr, Brandacher, Gerald, Schneider., Joel P.
Publicado no Nat Nanotechnol (2015)

“.... The peptide, which contains a photocaged glutamic acid, forms a solid-like gel in a syringe and can be shear...”
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20

Dorsal hippocampus contributes to model-based planning

Dorsal hippocampus contributes to model-based planning

Por Miller, Kevin J., Botvinick, Matthew M., Brody, Carlos D.
Publicado no Nat Neurosci (2017)

“...Planning can be defined as action selection that leverages an internal model of the outcomes likely...”
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