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Membrane-anchoring stabilizes and favors secretion of New Delhi Metallo-β-lactamase
Carbapenems, “last resort” β-lactam antibiotics, are inactivated by zinc-dependent metallo-β-lactamases (MBLs). The host innate immune response withholds nutrient metal ions from microbial pathogens by releasing metal-chelating proteins such as calprotectin. We show that metal sequestration is detri...
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| Published in: | Nat Chem Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4912412/ https://ncbi.nlm.nih.gov/pubmed/27182662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2083 |
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