Resultados da pesquisa - (( drug model develop type ) or ( drug ((loss develop) OR (less developed)) type ))

Pesquisas alternativas:
model develop » model develops (Expandir a Pesquisa), models develop (Expandir a Pesquisa), model developed (Expandir a Pesquisa)
develop type » developing type (Expandir a Pesquisa)
loss develop » locus develop (Expandir a Pesquisa), boys develop (Expandir a Pesquisa), ipscs develop (Expandir a Pesquisa)
drug model » drug models (Expandir a Pesquisa), drugs model (Expandir a Pesquisa), drug mode (Expandir a Pesquisa)

1

Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma

Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma

Por Christopher S. Koivisto, Melodie Parrish, Santosh B. Bonala, Soo Ngoi, Adrian Torres, James Gallagher, Rebekah Sanchez-Hodge, Victor Zeinner, Georges J. Nahhas, Bei Liu, David E. Cohn, Floor J. Backes, Paul J. Goodfellow, Helen M. Chamberlin, Gustavo Leone
Publicado em 2020-10-01

Assuntos: “...Preclinical drug evaluation...”
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2

Does it really matter which drug you choose? An examination of the influence of type of drug on type of risky sexual behavior

Does it really matter which drug you choose? An examination of the influence of type of drug on type of risky sexual behavior

Por Ritchwood, Tiarney D., DeCoster, Jamie, Metzger, Isha, Bolland, John M., Danielson, Carla K.
Publicado no Addict Behav (2016)

“... the consideration of type of SU, and particular combinations of substances, on RSBs in intervention development....”
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3

The value of assessing cognitive function in drug development

The value of assessing cognitive function in drug development

Por Wesnes, Keith A.
Publicado em 2000

“... assessing a variety of cognitive functions is crucial in helping differentiate drugs, types of dementia...”
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4

Box-Behnken experimental design in the development of a nasal drug delivery system of model drug hydroxyurea: Characterization of viscosity, in vitro drug release, droplet size, and dynamic surface tension

Box-Behnken experimental design in the development of a nasal drug delivery system of model drug...

Por Dayal, Pankaj, Pillay, Viness, Babu, R. Jayachandra, Singh, Mandip
Publicado em 2005

“... on the combined responses of viscosity, droplet size distribution (DSD), and drug release. Gel formulations...”
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5

Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment

Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment

Por Hoffman-Luca, C. Gianna, Yang, Chao-Yie, Lu, Jianfeng, Ziazadeh, Daniel, McEachern, Donna, Debussche, Laurent, Wang, Shaomeng
Publicado no PLoS One (2015)

“.... Computational modeling suggested that a p53 tetramer containing two wild-type p53 molecules and two C176F...”
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6

Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1 Drug Resistance in a Macaque Model for Antiretroviral Therapy

Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1 Drug Resistance in a Macaque Model for Antiretroviral Therapy

Por Ambrose, Zandrea, Palmer, Sarah, Boltz, Valerie F., Kearney, Mary, Larsen, Kay, Polacino, Patricia, Flanary, Leon, Oswald, Kelli, Piatak, Michael, Smedley, Jeremy, Shao, Wei, Bischofberger, Norbert, Maldarelli, Frank, Kimata, Jason T., Mellors, John W., Hu, Shiu-Lok, Coffin, John M., Lifson, Jeffrey D., KewalRamani, Vineet N.
Publicado em 2007

“... animals models, where therapy manipulation is less constrained. We examined a pigtail macaque infection...”
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7

Development of an Improved 3D in vitro Intestinal Model to Perform Permeability Studies of Paracellular Compounds

Development of an Improved 3D in vitro Intestinal Model to Perform Permeability Studies of Paracellular Compounds

Por Maria Helena Macedo, Maria Helena Macedo, Elena Martínez, Elena Martínez, Elena Martínez, Cristina C. Barrias, Cristina C. Barrias, Bruno Sarmento, Bruno Sarmento
Publicado em 2020-09-01

Assuntos: “...drug development...”
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8

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Por Yuthavong, Yongyuth, Tarnchompoo, Bongkoch, Vilaivan, Tirayut, Chitnumsub, Penchit, Kamchonwongpaisan, Sumalee, Charman, Susan A., McLennan, Danielle N., White, Karen L., Vivas, Livia, Bongard, Emily, Thongphanchang, Chawanee, Taweechai, Supannee, Vanichtanankul, Jarunee, Rattanajak, Roonglawan, Arwon, Uthai, Fantauzzi, Pascal, Yuvaniyama, Jirundon, Charman, William N., Matthews, David
Publicado em 2012

“..., and preclinical development of a selective, highly efficacious, and orally available antimalarial drug candidate...”
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9

Associations of statins and antiretroviral drugs with the onset of type 2 diabetes among HIV-1-infected patients

Associations of statins and antiretroviral drugs with the onset of type 2 diabetes among HIV-1-infected patients

Por Spagnuolo, Vincenzo, Galli, Laura, Poli, Andrea, Salpietro, Stefania, Gianotti, Nicola, Piatti, Piermarco, Cossarini, Francesca, Vinci, Concetta, Carini, Elisabetta, Lazzarin, Adriano, Castagna, Antonella
Publicado no BMC Infect Dis (2017)

“... investigated the associations of statin use and exposure to antiretroviral drugs with type 2 DM onset in a...”
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10

Developing a Patient-Directed Policy Framework for Managing Orphan and Ultra-Orphan Drugs Throughout Their Lifecycle

Developing a Patient-Directed Policy Framework for Managing Orphan and Ultra-Orphan Drugs Throughout Their Lifecycle

Por Menon, Devidas, Stafinski, Tania, Dunn, Andrea, Wong-Rieger, Durhane
Publicado no Patient (2015)

“... to discuss issues around orphan and ultra-orphan drug development, access, and coverage, and identify...”
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11

Development of a Novel In Vitro Human Tissue-Based Angiogenesis Assay to Evaluate the Effect of Antiangiogenic Drugs

Development of a Novel In Vitro Human Tissue-Based Angiogenesis Assay to Evaluate the Effect of Antiangiogenic Drugs

Por Woltering, Eugene A., Lewis, James M., Maxwell, P. Johnstone, Frey, Daniel J., Wang, Yi-Zarn, Rothermel, John, Anthony, Catherine T., Balster, Douglas A., O’Leary, J. Patrick, Harrison, Lynn H.
Publicado em 2003

“...OBJECTIVE: To describe a novel in vitro human tissue-based angiogenic model that can predict...”
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12

Developing an in vitro screening assay platform for evaluation of antifibrotic drugs using precision-cut liver slices

Developing an in vitro screening assay platform for evaluation of antifibrotic drugs using precision-cut liver slices

Por Sadasivan, Satish Kumar, Siddaraju, Nethra, Khan, Khaiser Mehdi, Vasamsetti, Balamuralikrishna, Kumar, Nimisha R, Haridas, Vibha, Reddy, Madhusudhan B, Baggavalli, Somesh, Oommen, Anup M, Pralhada Rao, Raghavendra
Publicado no Fibrogenesis Tissue Repair (2014)

“...BACKGROUND: Precision-cut liver slices present different cell types of liver in a physiological...”
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13

Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1.

Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1.

Por Gabriele Möller, Bettina Husen, Dorota Kowalik, Leena Hirvelä, Dariusz Plewczynski, Leszek Rychlewski, Josef Messinger, Hubert Thole, Jerzy Adamski
Publicado em 2010-01-01

“... in the rodent model during preclinical optimization steps. Potentially active human-relevant drugs, therefore...”
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14

Species Used for Drug Testing Reveal Different Inhibition Susceptibility for 17beta-Hydroxysteroid Dehydrogenase Type 1

Species Used for Drug Testing Reveal Different Inhibition Susceptibility for 17beta-Hydroxysteroid Dehydrogenase Type 1

Por Möller, Gabriele, Husen, Bettina, Kowalik, Dorota, Hirvelä, Leena, Plewczynski, Dariusz, Rychlewski, Leszek, Messinger, Josef, Thole, Hubert, Adamski, Jerzy
Publicado em 2010

“.... Potentially active human-relevant drugs, therefore, would no longer be further developed. Activity...”
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15

Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus

Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus

Por Elisa S. Roesti, Christina N. Boyle, Daniel T. Zeman, Marcos Sande-Melon, Federico Storni, Gustavo Cabral-Miranda, Alexander Knuth, Thomas A. Lutz, Monique Vogel, Martin F. Bachmann
Publicado em 2020-03-01

“...Type 2 diabetes mellitus (T2DM) is a chronic progressive disease characterized by insulin...”
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16

Multiscale Modeling of Functionalized Nanocarriers in Targeted Drug Delivery

Multiscale Modeling of Functionalized Nanocarriers in Targeted Drug Delivery

Por Liu, Jin, Bradley, Ryan, Eckmann, David M., Ayyaswamy, Portonovo S., Radhakrishnan, Ravi
Publicado em 2011

“... and diagnostic applications. In this paper we review the recent development of models at multiple length and time...”
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17

A Novel Aminotetralin-Type Serotonin (5-HT) (2C) Receptor-Specific Agonist and 5-HT(2A) Competitive Antagonist/5-HT(2B) Inverse Agonist with Preclinical Efficacy for Psychoses

A Novel Aminotetralin-Type Serotonin (5-HT) (2C) Receptor-Specific Agonist and 5-HT(2A) Competitive...

Por Canal, Clinton E., Morgan, Drake, Felsing, Daniel, Kondabolu, Krishnakanth, Rowland, Neil E., Robertson, Kimberly L., Sakhuja, Rajeev, Booth, Raymond G.
Publicado em 2014

Assuntos: “...Drug Discovery and Translational Medicine...”
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18

Otitis media induced by peptidoglycan-polysaccharide (PGPS) in TLR2-deficient (Tlr2(−/−)) mice for developing drug therapy

Otitis media induced by peptidoglycan-polysaccharide (PGPS) in TLR2-deficient (Tlr2(−/−)) mice for developing drug therapy

Por Zhang, Xiaolin, Zheng, Tihua, Sang, Lu, Apisa, Luke, Zhao, Hongchun, Fu, Fenghua, Wang, Qingzhu, Wang, Yanfei, Zheng, Qing Yin
Publicado no Infect Genet Evol (2015)

“... animal model. Peptidoglycan-polysaccharide (PGPS) of the bacterial cell wall can induce inflammation...”
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19

Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson’s Disease: Drug Effects of Withania somnifera (Dunal) Administration

Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model...

Por De Rose, Francescaelena, Marotta, Roberto, Poddighe, Simone, Talani, Giuseppe, Catelani, Tiziano, Setzu, Maria Dolores, Solla, Paolo, Marrosu, Francesco, Sanna, Enrico, Kasture, Sanjay, Acquas, Elio, Liscia, Anna
Publicado no PLoS One (2016)

“... methanolic extract (Wse) on the LRRK2 loss-of-function Dm model of PD. To this end mutant and wild type (WT...”
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20

Effects of Brown Rice and White Rice on Expression of Xenobiotic Metabolism Genes in Type 2 Diabetic Rats

Effects of Brown Rice and White Rice on Expression of Xenobiotic Metabolism Genes in Type 2 Diabetic Rats

Por Maznah Ismail, Mustapha Umar Imam
Publicado em 2012-07-01

Assuntos: “...drug biotransformation...”
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