Preclinical assessment of MEK1/2 inhibitors for neurofibromatosis type 2–associated schwannomas reveals differences in efficacy and drug resistance development

Por Fuse, Marisa A, Dinh, Christine T, Vitte, Jeremie, Kirkpatrick, Joanna, Mindos, Thomas, Plati, Stephani Klingeman, Young, Juan I, Huang, Jie, Carlstedt, Annemarie, Franco, Maria Clara, Brnjos, Konstantin, Nagamoto, Jackson, Petrilli, Alejandra M, Copik, Alicja J, Soulakova, Julia N, Bracho, Olena, Yan, Denise, Mittal, Rahul, Shen, Rulong, Telischi, Fred F, Morrison, Helen, Giovannini, Marco, Liu, Xue-Zhong, Chang, Long-Sheng, Fernandez-Valle, Cristina
Publicado no Neuro Oncol (2019)

Development of drug resistance in a murine mammary tumour.

Por McMillan, T. J., Stephens, T. C., Steel, G. G.
Publicado em 1985

The molecular biology and HPV drug responsiveness of cynomolgus macaque papillomaviruses support their use in the development of a relevant in vivo model for antiviral drug testing

Por Tombak, Eva-Maria, Männik, Andres, Burk, Robert D., Le Grand, Roger, Ustav, Ene, Ustav, Mart
Publicado no PLoS One (2019)

Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs

Por Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Maxim I. Sorokin, Maxim I. Sorokin, Maxim I. Sorokin, Anna A. Emelianova, Nikolay M. Borisov, Nikolay M. Borisov, Denis V. Kuzmin, Pieter Borger, Andrew V. Garazha, Anton A. Buzdin, Anton A. Buzdin, Anton A. Buzdin
Publicado em 2019-01-01

Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents

Por Yuan, Mingjun, Chua, Song Lin, Liu, Yang, Drautz-Moses, Daniela I, Yam, Joey Kuok Hoong, Aung, Thet Tun, Beuerman, Roger W, Salido, May Margarette Santillan, Schuster, Stephan C, Tan, Choon-Hong, Givskov, Michael, Yang, Liang, Nielsen, Thomas E
Publicado no Beilstein J Org Chem (2018)

Multiscale Design of Cell-Type–Specific Pharmacokinetic/Pharmacodynamic Models for Personalized Medicine: Application to Temozolomide in Brain Tumors

Por Ballesta, A, Zhou, Q, Zhang, X, Lv, H, Gallo, J M
Publicado em 2014

Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches

Por Bhattacharya, Sudin, Shoda, Lisl K.M., Zhang, Qiang, Woods, Courtney G., Howell, Brett A., Siler, Scott Q., Woodhead, Jeffrey L., Yang, Yuching, McMullen, Patrick, Watkins, Paul B., Andersen, Melvin E.
Publicado em 2012

CHARMM additive and polarizable force fields for biophysics and computer-aided drug design

Por Vanommeslaeghe, K., MacKerell, A. D.
Publicado no Biochim Biophys Acta (2014)

The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

Por Baechler, S. A., Factor, V. M., Dalla Rosa, I., Ravji, A., Becker, D., Khiati, S., Miller Jenkins, L. M., Lang, M., Sourbier, C., Michaels, S. A., Neckers, L. M., Zhang, H. L., Spinazzola, A., Huang, S. N., Marquardt, J. U., Pommier, Y.
Publicado no Nat Commun (2019)

Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment

Por Hoffman-Luca, C. Gianna, Yang, Chao-Yie, Lu, Jianfeng, Ziazadeh, Daniel, McEachern, Donna, Debussche, Laurent, Wang, Shaomeng
Publicado no PLoS One (2015)

GenoType(®) MTBDRsl assay for resistance to second‐line anti‐tuberculosis drugs

Por Theron, Grant, Peter, Jonny, Richardson, Marty, Warren, Rob, Dheda, Keertan, Steingart, Karen R
Publicado no Cochrane Database Syst Rev (2016)

Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs

Por Khan Suleiman A, Faisal Ali, Mpindi John, Parkkinen Juuso A, Kalliokoski Tuomo, Poso Antti, Kallioniemi Olli P, Wennerberg Krister, Kaski Samuel
Publicado em 2012-05-01

Flow cytometric analysis of Hoechst 33342 uptake as an indicator of multi-drug resistance in human lung cancer.

Por Morgan, S. A., Watson, J. V., Twentyman, P. R., Smith, P. J.
Publicado em 1989

DNA TOPOISOMERASE I INHIBITORS AMELIORATE SEIZURE-LIKE BEHAVIORS AND PARALYSIS IN A DROSOPHILA MODEL OF EPILEPSY

Por Song, Juan, Parker, Louise, Hormozi, Linda, Tanouye, Mark A.
Publicado em 2008

Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs

Por Khan, Suleiman A, Faisal, Ali, Mpindi, John Patrick, Parkkinen, Juuso A, Kalliokoski, Tuomo, Poso, Antti, Kallioniemi, Olli P, Wennerberg, Krister, Kaski, Samuel
Publicado em 2012

Development of a novel zebrafish xenograft model in ache mutants using liver cancer cell lines

Por Avci, M. Ender, Keskus, Ayse Gokce, Targen, Seniye, Isilak, M. Efe, Ozturk, Mehmet, Atalay, Rengul Cetin, Adams, Michelle M., Konu, Ozlen
Publicado no Sci Rep (2018)

Protective effects of Derinat, a nucleotide-based drug, on experimental traumatic brain injury, and its cellular mechanisms

Por E. A. Korneva, E. V. Dmitrienko, S. Miyamura, M. Noda, N. Akimoto
Publicado em 2021-12-01

Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ

Por Oviatt, Alexandria A., Kuriappan, Jissy A., Minniti, Elirosa, Vann, Kendra R., Onuorah, Princess, Minarini, Anna, De Vivo, Marco, Osheroff, Neil
Publicado no Bioorg Med Chem Lett (2018)

Cross species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80/Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum...

Por Molehin, Adebayo J., Sennoune, Souad R., Zhang, Weidong, Rojo, Juan U., Siddiqui, Arif J., Herrera, Karlie A., Johnson, Laura, Sudduth, Justin, May, Jordan, Siddiqui, Afzal A.
Publicado no Parasitol Res (2017)

Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity

Por de Boer, Richard, Smith, Ruben L., De Vos, Winnok H., Manders, Erik M. M., Brul, Stanley, van der Spek, Hans
Publicado no PLoS One (2015)