Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs

Despite the significant achievements in chemotherapy, cancer remains one of the leading causes of death. Target therapy revolutionized this field, but efficiencies of target drugs show dramatic variation among individual patients. Personalization of target therapies remains, therefore, a challenge i...

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Autors principals: Marianna A. Zolotovskaia, Maxim I. Sorokin, Anna A. Emelianova, Nikolay M. Borisov, Denis V. Kuzmin, Pieter Borger, Andrew V. Garazha, Anton A. Buzdin
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019-01-01
Col·lecció:Frontiers in Pharmacology
Matèries:
cancer
DNA mutation
molecular pathways
biomarker
target drugs
tyrosine kinase inhibitors
Accés en línia:https://www.frontiersin.org/article/10.3389/fphar.2019.00001/full
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