Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ

Etoposide is an anticancer drug that acts by inducing topoisomerase II-mediated DNA cleavage. Despite its wide use, etoposide is associated with some very serious side-effects including the development of treatment-related acute myelogenous leukemias. Etoposide targets both human topoisomerase IIα a...

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Publicado en:Bioorg Med Chem Lett
Main Authors: Oviatt, Alexandria A., Kuriappan, Jissy A., Minniti, Elirosa, Vann, Kendra R., Onuorah, Princess, Minarini, Anna, De Vivo, Marco, Osheroff, Neil
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097886/
https://ncbi.nlm.nih.gov/pubmed/30006062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.07.010
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