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Etoposide Quinone Is a Redox-Dependent Topoisomerase II Poison
Etoposide is a topoisomerase II poison that is used to treat a variety of human cancers. Unfortunately, 2–3% of patients treated with etoposide develop treatment-related leukemias characterized by 11q23 chromosomal rearrangements. The molecular basis for etoposide-induced leukemogenesis is not under...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3119725/ https://ncbi.nlm.nih.gov/pubmed/21595477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200438m |
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