Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches

We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. The concept of “toxicity pathways” is described in the context of the 2007 US National Academies of Science report, “Toxicity testing in the 21st Century: A Vision and A...

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Detalhes bibliográficos
Main Authors: Bhattacharya, Sudin, Shoda, Lisl K.M., Zhang, Qiang, Woods, Courtney G., Howell, Brett A., Siler, Scott Q., Woodhead, Jeffrey L., Yang, Yuching, McMullen, Patrick, Watkins, Paul B., Andersen, Melvin E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522076/
https://ncbi.nlm.nih.gov/pubmed/23248599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2012.00462
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