Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses

Drug-induced liver injury (DILI) remains an adverse event of significant concern for drug development and marketed drugs, and the field would benefit from better tools to identify liver liabilities early in development and/or to mitigate potential DILI risk in otherwise promising drugs. DILIsym soft...

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Vydáno v:Gene Regul Syst Bio
Hlavní autoři: Shoda, Lisl KM, Battista, Christina, Siler, Scott Q, Pisetsky, David S, Watkins, Paul B, Howell, Brett A
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2017
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459514/
https://ncbi.nlm.nih.gov/pubmed/28615926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1177625017696074
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