Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses

Drug-induced liver injury (DILI) remains an adverse event of significant concern for drug development and marketed drugs, and the field would benefit from better tools to identify liver liabilities early in development and/or to mitigate potential DILI risk in otherwise promising drugs. DILIsym soft...

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Опубликовано в: :Gene Regul Syst Bio
Главные авторы: Shoda, Lisl KM, Battista, Christina, Siler, Scott Q, Pisetsky, David S, Watkins, Paul B, Howell, Brett A
Формат: Artigo
Язык:Inglês
Опубликовано: SAGE Publications 2017
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459514/
https://ncbi.nlm.nih.gov/pubmed/28615926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1177625017696074
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