A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

Entolimod (CBLB502) is a Toll-like receptor 5 agonist in development as a single-dose countermeasure against total body irradiation. Efficacy can be assessed from animal studies, but the “Animal Rule” does not apply to safety assessment. Marked elevations of serum aminotransferases (exceeding 1,000...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Howell, B A, Siler, S Q, Shoda, L K M, Yang, Y, Woodhead, J L, Watkins, P B
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944113/
https://ncbi.nlm.nih.gov/pubmed/24500662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.74
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker