A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

Entolimod (CBLB502) is a Toll-like receptor 5 agonist in development as a single-dose countermeasure against total body irradiation. Efficacy can be assessed from animal studies, but the “Animal Rule” does not apply to safety assessment. Marked elevations of serum aminotransferases (exceeding 1,000...

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Detalhes bibliográficos
Main Authors: Howell, B A, Siler, S Q, Shoda, L K M, Yang, Y, Woodhead, J L, Watkins, P B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944113/
https://ncbi.nlm.nih.gov/pubmed/24500662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.74
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