Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

Por Watkins, P B, Wrighton, S A, Schuetz, E G, Molowa, D T, Guzelian, P S
Publicado em 1987

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

Por Kolars, J C, Schmiedlin-Ren, P, Schuetz, J D, Fang, C, Watkins, P B
Publicado em 1992

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

Por Watkins, P B, Murray, S A, Winkelman, L G, Heuman, D M, Wrighton, S A, Guzelian, P S
Publicado em 1989

MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

Por Yang, Y., Nadanaciva, S., Will, Y., Woodhead, J. L., Howell, B. A., Watkins, P. B., Siler, S. Q.
Publicado no Pharm Res (2014)

Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats.

Por Wrighton, S A, Thomas, P E, Willis, P, Maines, S L, Watkins, P B, Levin, W, Guzelian, P S
Publicado em 1987

A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

Por Howell, B A, Siler, S Q, Shoda, L K M, Yang, Y, Woodhead, J L, Watkins, P B
Publicado em 2014

Identification of an inducible form of cytochrome P-450 in human liver.

Por Watkins, P B, Wrighton, S A, Maurel, P, Schuetz, E G, Mendez-Picon, G, Parker, G A, Guzelian, P S
Publicado em 1985

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

Por Molowa, D T, Schuetz, E G, Wrighton, S A, Watkins, P B, Kremers, P, Mendez-Picon, G, Parker, G A, Guzelian, P S
Publicado em 1986

Serum proteomic profiling in patients with drug-induced liver injury

Por Bell, L. N., Vuppalanchi, R., Watkins, P. B., Bonkovsky, H. L., Serrano, J., Fontana, R. J., Wang, M., Rochon, J., Chalasani, N.
Publicado em 2012

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

Por Lown, K S, Bailey, D G, Fontana, R J, Janardan, S K, Adair, C H, Fortlage, L A, Brown, M B, Guo, W, Watkins, P B
Publicado em 1997

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI

Por Woodhead, J L, Yang, K, Brouwer, K L R, Siler, S Q, Stahl, S H, Ambroso, J L, Baker, D, Watkins, P B, Howell, B A
Publicado em 2014

The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers

Por Harrill, A H, Roach, J, Fier, I, Eaddy, J S, Kurtz, C L, Antoine, D J, Spencer, D M, Kishimoto, T K, Pisetsky, D S, Park, B K, Watkins, P B
Publicado no Clin Pharmacol Ther (2012)

Comparative analysis of portal hepatic infiltrating leucocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis

Por Foureau, D M, Walling, T L, Maddukuri, V, Anderson, W, Culbreath, K, Kleiner, D E, Ahrens, W A, Jacobs, C, Watkins, P B, Fontana, R J, Chalasani, N, Talwalkar, J, Lee, W M, Stolz, A, Serrano, J, Bonkovsky, H L
Publicado no Clin Exp Immunol (2015)

Blood gene expression signatures predict exposure levels

Por Bushel, P. R., Heinloth, A. N., Li, J., Huang, L., Chou, J. W., Boorman, G. A., Malarkey, D. E., Houle, C. D., Ward, S. M., Wilson, R. E., Fannin, R. D., Russo, M. W., Watkins, P. B., Tennant, R. W., Paules, R. S.
Publicado em 2007