Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

The increase in oral availability of felodipine and other commonly used medications when taken with grapefruit juice has been assumed to be due to inhibition of CYP3A4, a cytochrome P450 that is present in liver and intestine. To evaluate the effect of repeated grapefruit juice ingestion on CYP3A4 e...

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Publicat a:J Clin Invest
Autors principals: Lown, K S, Bailey, D G, Fontana, R J, Janardan, S K, Adair, C H, Fortlage, L A, Brown, M B, Guo, W, Watkins, P B
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508096/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9153299/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119439
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