Pharmacokinetic analysis of felodipine–grapefruit juice interaction based on an irreversible enzyme inhibition model

AIMS: Ingestion of grapefruit juice (GFJ) alters the pharmacokinetics of various orally administered drugs. Quantitative evaluation of this GFJ–drug interaction is required for the proper clinical management of patients. METHODS: Using felodipine as a model drug, we constructed a pharmacokinetic mod...

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Main Authors: Takanaga, Hitomi, Ohnishi, Ayako, Matsuo, Hirotami, Murakami, Hideyasu, Sata, Hiroko, Kuroda, Ken, Urae, Akinori, Higuchi, Shun, Sawada, Yasufumi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014888/
https://ncbi.nlm.nih.gov/pubmed/10606837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00140.x
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