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Pharmacokinetic analysis of felodipine–grapefruit juice interaction based on an irreversible enzyme inhibition model
AIMS: Ingestion of grapefruit juice (GFJ) alters the pharmacokinetics of various orally administered drugs. Quantitative evaluation of this GFJ–drug interaction is required for the proper clinical management of patients. METHODS: Using felodipine as a model drug, we constructed a pharmacokinetic mod...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Science Inc
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014888/ https://ncbi.nlm.nih.gov/pubmed/10606837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00140.x |
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