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Major determinant factors of the extent of interaction between grapefruit juice and calcium channel antagonists
AIM: To evaluate quantitatively the influence of bioavailability and plasma unbound fraction (f(u)) on the extent of interaction between grapefruit juice (GFJ) and calcium antagonists. METHODS: The extent of drug–GFJ interaction was evaluated from reported clinical interaction studies of 11 calcium...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Science Inc
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1885101/ https://ncbi.nlm.nih.gov/pubmed/16842394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02636.x |
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