Major determinant factors of the extent of interaction between grapefruit juice and calcium channel antagonists

AIM: To evaluate quantitatively the influence of bioavailability and plasma unbound fraction (f(u)) on the extent of interaction between grapefruit juice (GFJ) and calcium antagonists. METHODS: The extent of drug–GFJ interaction was evaluated from reported clinical interaction studies of 11 calcium...

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Detalhes bibliográficos
Main Authors: Ohnishi, Ayako, Ohtani, Hisakazu, Sawada, Yasufumi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885101/
https://ncbi.nlm.nih.gov/pubmed/16842394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02636.x
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