Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux

1. We investigated the effects of grapefruit juice (GFJ) and orange juice (OJ) on drug transport by MDR1 P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2), which are efflux transporters expressed in human small intestine. 2. We examined the transcellular transport and uptake of [(3)H]v...

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Detalhes bibliográficos
Main Authors: Honda, Yoko, Ushigome, Fumihiko, Koyabu, Noriko, Morimoto, Satoshi, Shoyama, Yukihiro, Uchiumi, Takeshi, Kuwano, Michihiko, Ohtani, Hisakazu, Sawada, Yasufumi
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575941/
https://ncbi.nlm.nih.gov/pubmed/15504753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706008
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