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Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux
1. We investigated the effects of grapefruit juice (GFJ) and orange juice (OJ) on drug transport by MDR1 P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2), which are efflux transporters expressed in human small intestine. 2. We examined the transcellular transport and uptake of [(3)H]v...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1575941/ https://ncbi.nlm.nih.gov/pubmed/15504753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706008 |
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