Chargement en cours...
Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters
Elevations in serum bilirubin during drug treatment may indicate global liver dysfunction and a high risk of liver failure. However, drugs also can increase serum bilirubin in the absence of hepatic injury by inhibiting specific enzymes/transporters. We constructed a mechanistic model of bilirubin d...
Enregistré dans:
| Publié dans: | Clin Pharmacol Ther |
|---|---|
| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2017
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5367379/ https://ncbi.nlm.nih.gov/pubmed/28074467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.619 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|