Resultados da pesquisa - (( _ nat (com OR cap) can now ) OR ((( a nayl clamp j now ) OR ( j e combs cantones now ))))*

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The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

Por Patel, Basant K, Gavin-Smyth, Jackie, Liebman, Susan W
Publicado em 2009

“...Although many proteins can misfold into a self-seeding amyloid-like conformation1, only six...”
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Somatic Mutations in the Angiopoietin-Receptor TIE2 Can Cause Both Solitary and Multiple Sporadic Venous Malformations

Por Limaye, Nisha, Wouters, Vinciane, Uebelhoer, Melanie, Tuominen, Marjut, Wirkkala, Riikka, Mulliken, John B., Eklund, Lauri, Boon, Laurence M., Vikkula, Miikka
Publicado em 2008

“... inherited form of venous anomalies, mucocutaneous venous malformations (VMCM)1-4. We now identified a...”
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Quantitative optical trapping on single cellular organelles in cell extract

Por Barak, Pradeep, Rai, Ashim, Rai, Priyanka, Mallik, Roop
Publicado em 2012

“... on single organelles of unknown size in cell extract. Native motor-complexes can now be interrogated...”
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Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

Por Gutierrez-Achury, Javier, Zhernakova, Alexandra, Pulit, Sara L., Trynka, Gosia, Hunt, Karen A., Romanos, Jihane, Raychaudhuri, Soumya, van Heel, David A., Wijmenga, Cisca, de Bakker, Paul I.W.
Publicado no Nat Genet (2015)

“... that account for 18% of the genetic risk. Together with the 57 known non-MHC loci, genetic variation can now...”
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Differential confounding of rare and common variants in spatially structured populations

Por Mathieson, Iain, McVean, Gil
Publicado em 2012

“... demonstrate that rare variants can show a systematically different and typically stronger stratification than...”
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Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration

Por Lobanova, Ekaterina S., Finkelstein, Stella, Li, Jing, Travis, Amanda M., Hao, Ying, Klingeborn, Mikael, Skiba, Nikolai P., Deshaies, Raymond J., Arshavsky, Vadim Y.
Publicado no Nat Commun (2018)

“... independent, i.e., targeting common pathological conditions arising from many disease-causing mutations...”
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Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering

Por Kelley, Shana O., Mirkin, Chad A., Walt, David R., Ismagilov, Rustem F., Toner, Mehmet, Sargent, Edward H.
Publicado no Nat Nanotechnol (2014)

“... that incorporate nanoscale features can now rapidly detect disease-related nucleic acids expressed in patient...”
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Optogenetic pharmacology for control of native neuronal signaling proteins

Por Kramer, Richard H, Mourot, Alexandre, Adesnik, Hillel
Publicado no Nat Neurosci (2013)

“...The optical neuroscience revolution is transforming how we study neural circuits. By providing a...”
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Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA

Por Lam, Bianca J., Joyce, Gerald F.
Publicado em 2009

“... in a sample. This process is analogous to quantitative PCR (qPCR), but can be generalized to a wide...”
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FOXA1 is a critical determinant of Estrogen Receptor function and endocrine response

Por Hurtado, Antoni, Holmes, Kelly A., Ross-Innes, Caryn S., Schmidt, Dominic, Carroll, Jason S.
Publicado em 2010

“... to the genome correlates with the Forkhead protein FOXA1 (HNF3α). We now show that FOXA1 is a critical...”
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A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

Por Koga, Hiroshi, Martinez-Vicente, Marta, Macian, Fernando, Verkhusha, Vladislav V, Cuervo, Ana Maria
Publicado em 2011

“... in the intracellular fluorescence. The CMA reporter can be utilized in a broad variety of cells and is suitable...”
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Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator

Por Feng, Ying, Chen, Mo, Manley, James L
Publicado em 2008

“... dephosphorylated. We now show that phosphorylated SRp38 functions as a sequence-specific splicing activator. Unlike...”
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Phymm and PhymmBL: Metagenomic Phylogenetic Classification with Interpolated Markov Models

Por Brady, Arthur, Salzberg, Steven L.
Publicado em 2009

“... sequence reads into groups representing the same or similar taxa, a prerequisite for genome assembly...”
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Invariant natural killer T cells recognize lipid self-antigen induced by microbial danger signals

Por Brennan, Patrick J., Tatituri, Raju V.V., Brigl, Manfred, Kim, Edy Y., Tuli, Amit, Sanderson, Joseph P., Gadola, Stephan D., Hsu, Fong-Fu, Besra, Gurdyal S., Brenner, Michael B.
Publicado em 2011

“... lipid antigens are present, suggesting a role for lipid self-antigen. We now demonstrate...”
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MYC Suppresses Cancer Metastasis by Direct Transcriptional Silencing of αv and β3 Integrin Subunits

Por Liu, Hong, Radisky, Derek C., Yang, Dun, Xu, Ren, Radisky, Evette S., Bissell, Mina J., Bishop, J. Michael
Publicado em 2012

“... oncogene can also act as a suppressor of cell motility, invasiveness and metastasis. Overexpression of MYC...”
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Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

Por Shock, David D., Freudenthal, Bret D., Beard, William A., Wilson, Samuel H.
Publicado no Nat Chem Biol (2017)

“... nucleotide incorporation, polymerases also catalyze a reverse reaction, pyrophosphorolysis, removing the DNA...”
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Insulin-like signalling to the maternal germline controls progeny response to osmotic stress

Por Burton, Nicholas O., Furuta, Tokiko, Webster, Amy K., Kaplan, Rebecca E. W., Baugh, L. Ryan, Arur, Swathi, Horvitz, H. Robert
Publicado no Nat Cell Biol (2017)

“... cells to germ cells(1), a hypothesis now known as the Weismann barrier. However, recent studies have...”
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Extracellular histones are major mediators of death in sepsis

Por Xu, Jun, Zhang, Xiaomei, Pelayo, Rosana, Monestier, Marc, Ammollo, Concetta T., Semeraro, Fabrizio, Taylor, Fletcher B., Esmon, Naomi, Lupu, Florea, Esmon, Charles T.
Publicado em 2009

“...Hyper–inflammatory responses can lead to a variety of diseases including sepsis1. We now report...”
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Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation

Por Wuttke, Thomas V., Markopoulos, Foivos, Padmanabhan, Hari, Wheeler, Aaron P., Murthy, Venkatesh N., Macklis, Jeffrey D.
Publicado no Nat Neurosci (2018)

“... energy balance circuitry. We now demonstrate that postnatal neocortical connectivity can be reconstituted...”
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Invariant NKT cells modulate the suppressive activity of Serum Amyloid A-differentiated IL-10-secreting neutrophils

Por De Santo, Carmela, Arscott, Ramon, Booth, Sarah, Karydis, Ioannis, Jones, Margaret, Asher, Ruth, Salio, Mariolina, Middleton, Mark, Cerundolo, Vincenzo
Publicado em 2010

“... their plasticity remain unclear. We now show that systemic serum amyloid A-1 (SAA-1) controls the plasticity...”
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